Catálogo de publicaciones - revistas

<jats:title>The nongenetic roles of the nucleus</jats:title> <jats:p>The eukaryotic cell nucleus provides a home for the genetic material and accessory proteins. As a physical entity, the nucleus also plays an important role in cell dynamics. Bustin and Misteli Review the impacts that the nucleus can have as a nongenetic force. For example, compacted DNA and the nuclear membrane affect nuclear morphology, the cellular response to mechanical force, cell migration, and cell signaling. Chromatin is not only affected by physical forces in cells but participates in a crosstalk of signaling inside cells.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad6933">10.1126/science.aad6933</jats:related-article> </jats:p>

<jats:title>Faulty channels, not faulty synapses</jats:title> <jats:p> SHANK3 is a widely expressed scaffolding protein that is enriched in postsynaptic specializations. In mutant mice, SHANK3 mutations cause autism-like behavioral changes and exhibit alterations in synaptic transmission. Yi <jats:italic>et al.</jats:italic> produced human neurons lacking SHANK3 but not other genes that are also involved in the autism-like disease Phelan-McDermid syndrome. Instead of affecting synapses, SHANK3 mutations primarily caused a channelopathy, with the major phenotype consisting of a specific impairment of HCN channels. Chronic impairment of membrane currents through channelopathy could account for the phenotypes observed in Phelan-McDermid neurons, such as alterations in cognitive functions and the predisposition to epilepsy. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaf2669">10.1126/science.aaf2669</jats:related-article> </jats:p>

<jats:p>Large-scale research facilities and new technology development have been essential to answering difficult, often intransigent scientific questions that would otherwise be inaccessible. The recent exciting discovery of gravitational waves by the Laser Interferometer Gravitational-Wave Observatory (LIGO) is but one of many startling findings that argue for major investments in large- and mid-scale instrumentation development. But such instruments and facilities are just one type of infrastructure that urgently needs investment. Routine laboratories that underpin most scientific activity are equally critical to progress, but in many cases have long been neglected and are deteriorating. A comprehensive strategy for updating these facilities and other infrastructure elements is essential for accelerating scientific momentum.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p> Ambitious experiment will test whether rising CO <jats:sub>2</jats:sub> will boost the tropical carbon sink. </jats:p>

<jats:p>Review warns that new timeline could still be too optimistic.</jats:p>

<jats:p>U.K. engineers and funders take stock of failures as they design new prototypes.</jats:p>

<jats:p>Our metabolism runs faster than that of other apes, likely allowing us to evolve big brains.</jats:p>

<jats:p>Time to revise 14-day limit for growing IVF embryos?</jats:p>