Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Biotech company will sponsor historic high school science competition
Devi Shastri
Palabras clave: Multidisciplinary.
Pp. No disponible
U.S. should stick with troubled ITER fusion project, secretary of energy recommends
Adrian Cho
Palabras clave: Multidisciplinary.
Pp. No disponible
Not unexpectedly, a new drug-resistant ‘superbug’ pops up in the United States
Kelly Servick
Palabras clave: Multidisciplinary.
Pp. No disponible
In dramatic statement, European leaders call for ‘immediate’ open access to all scientific papers by 2020
Martin Enserink
Palabras clave: Multidisciplinary.
Pp. No disponible
U.S. advisers sign off on plan for reviewing risky virus studies
Jocelyn Kaiser
Palabras clave: Multidisciplinary.
Pp. No disponible
Top stories: Mysterious Neandertal cave rings, booming squid populations, and a congressman’s push for Alpha Centauri
Patrick Monahan
Palabras clave: Multidisciplinary.
Pp. No disponible
Questions abound after study links tumors to cellphone radiation
Warren Cornwall
Palabras clave: Multidisciplinary.
Pp. No disponible
Elsewhere in Science: Funding Zika research, countering implicit bias, and more
Rachel Bernstein
Palabras clave: Multidisciplinary.
Pp. No disponible
Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation
Alex Rialdi; Laura Campisi; Nan Zhao; Arvin Cesar Lagda; Colette Pietzsch; Jessica Sook Yuin Ho; Luis Martinez-Gil; Romain Fenouil; Xiaoting Chen; Megan Edwards; Giorgi Metreveli; Stefan Jordan; Zuleyma Peralta; Cesar Munoz-Fontela; Nicole Bouvier; Miriam Merad; Jian Jin; Matthew Weirauch; Sven Heinz; Chris Benner; Harm van Bakel; Christopher Basler; Adolfo García-Sastre; Alexander Bukreyev; Ivan Marazzi
<jats:title>Unwinding DNA and unleasing inflammation</jats:title> <jats:p> Fighting infections often comes with collateral damage, which sometimes can be deadly. For instance, in septic shock, the overwhelming release of inflammatory mediators drives multi-organ failure. Rialdi <jats:italic>et al.</jats:italic> now report a potential new therapeutic target for controlling excessive inflammation: the DNA unwinding enzyme topoisomerase I (Top1) (see the Perspective by Pope and Medzhitov). Upon infection, Top1 specifically localizes to the promoters of pathogen-induced genes and promotes their transcription by helping to recruit RNA polymerase II. Pharmacological inhibition of Top1 in a therapeutic setting increased survival in several mouse models of severe microbially induced inflammation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad7993">10.1126/science.aad7993</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6289" page="1058" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aag0365">1058</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
From neutral to new
H. J. Smith
Palabras clave: Multidisciplinary.
Pp. i-1072