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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

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doi: 10.1126/science.aad9745

A force-generating machinery maintains the spindle at the cell center during mitosis

Carlos Garzon-Coral; Horatiu A. Fantana; Jonathon Howard

<jats:title>Forcing the spindle to the cell center</jats:title> <jats:p> As a cell divides, the mitotic spindle segregates chromosomes to daughter cells. It does so while maintaining a centralized position; however, the mechanism for spindle placement is unclear. Garzon-Coral <jats:italic>et al.</jats:italic> used magnetic tweezers to show that the dynamical properties of the astral microtubules act as a force-generating machinery to keep the spindle at the cell center. The stiffness of the spring-like force increases during anaphase and also with decreasing cell size. This machinery is strong enough to quench thermal fluctuations to ensure precise localization of the spindle, but soft enough to allow molecular force generators to fine-tune the position of the mitotic spindle. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6289" page="1124" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad9745">1124</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1124-1127

doi: 10.1126/science.352.6289.1128-b

Webinar | Key signaling pathways in cancer: Links to developmental biology

Elaine Fuchs; Benjamin L. Allen; Rik Derynck

<jats:p>It is notable that the same pathways governing the cell growth, death, and differentiation decisions made during embryonic development are also common drivers of adult malignancy. In this webinar, we will explore the idea that a better understanding of developmental biology signaling pathways will advance our understanding of adult tumors and cancer stem cells as well as boost our ability to create effective therapeutics to fight a broad array of cancers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1128-1128

doi: 10.1126/science.352.6289.1128-a

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1128-1128

doi: 10.1126/science.352.6289.1138