Catálogo de publicaciones - revistas

<jats:title>Expanded proteomic analysis of metabolism</jats:title> <jats:p> Combined analysis of large data sets characterizing genes, transcripts, and proteins can elucidate biological functions and disease processes. Williams <jats:italic>et al.</jats:italic> report an exceptionally detailed characterization of mitochondrial function in a genetic reference panel of recombinant inbred mice. They measured the metabolic function of nearly 400 mice under various environmental conditions and collected detailed quantitative information from livers of the animals on over 25,000 transcripts. These data were integrated with quantitation of over 2500 proteins and nearly 1000 metabolites. Such analysis showed a frequent lack of correlation of transcript and protein abundance, enabled the identification of genomic variants of mitochondrial enzymes that caused inborn errors in metabolism, and revealed two genes that appear to function in cholesterol metabolism. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad0189">10.1126/science.aad0189</jats:related-article> </jats:p>

<jats:title>An end to gene transcription</jats:title> <jats:p>Much attention has been focused on regulating the start of gene transcription. But transcription must also be terminated, and the mechanisms are only now being defined in detail in eukaryotes. Proudfoot reviews how termination happens for RNA polymerase II genes, mainly in mammals, covering the various steps that can lead to messenger RNA (mRNA) 3′ end formation and how they can be regulated. Termination can occur at various positions throughout the gene, forming the wild-type mRNA, preventing the synthesis of aberrant mRNAs, or generating alternative mRNAs with different regulatory or coding properties.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad9926">10.1126/science.aad9926</jats:related-article> </jats:p>

<jats:p> In a mere 50 years, robots have gone from being a topic of science fiction to becoming an integral part of modern society. They now are ubiquitous on factory floors, build complex deep-sea installations, explore icy worlds beyond the reach of humans, and assist in precision surgeries. These robots are improving our health, adding to our scientific understanding, raising productivity, and performing tasks that humans cannot do. The rapid increase in the capabilities, varieties, and applications of robots has been built on scientific and engineering research into power and actuation systems, artificial intelligence, onboard navigation, environmental sensors, manipulators, control systems, novel materials, microfluidics, systems integration, and many other advances. With this growth, the research community that is engaged in robotics has expanded globally. To help meet the need to communicate discoveries across all domains of robotics research, we are proud to announce that <jats:italic>Science Robotics</jats:italic> is open for submissions. </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Fragmentary “hobbitlike” fossils show evolution of dwarf human on Indonesian island.</jats:p>

<jats:p>Regulation and commercialization of fecal transplants could make poop providers obsolete.</jats:p>

<jats:p> Instead of sending CO <jats:sub>2</jats:sub> up a smokestack, researchers in Iceland turn it into rock. </jats:p>

<jats:p>Growing pains arise for researchers using online platform.</jats:p>