Catálogo de publicaciones - revistas

<jats:title>Codes of conduct in autonomous vehicles</jats:title> <jats:p> When it becomes possible to program decision-making based on moral principles into machines, will self-interest or the public good predominate? In a series of surveys, Bonnefon <jats:italic>et al.</jats:italic> found that even though participants approve of autonomous vehicles that might sacrifice passengers to save others, respondents would prefer not to ride in such vehicles (see the Perspective by Greene). Respondents would also not approve regulations mandating self-sacrifice, and such regulations would make them less willing to buy an autonomous vehicle. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6293" page="1573" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf2654">1573</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6293" page="1514" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf9534">1514</jats:related-article> </jats:p>

<jats:title>Clues to cancer from an identity change</jats:title> <jats:p> The prostate and seminal vesicle have closely related developmental histories and both are regulated by the same androgenic hormones. A better understanding of the molecular mechanisms controlling the development of the two tissues could help solve why cancer arises frequently in the prostate but only rarely in seminal vesicles. Working with cell and mouse models, Dutta <jats:italic>et al.</jats:italic> show that forced expression of a single gene, the homeobox gene <jats:italic>NKX3.1</jats:italic> , causes seminal vesicle epithelium to differentiate into prostate. <jats:italic>NKX3.1</jats:italic> regulates the expression of a gene program associated with prostate differentiation by interacting with the G9a histone methyltransferase. Disruption of this regulatory network probably contributes to prostate cancer development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6293" page="1576" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aad9512">1576</jats:related-article> </jats:p>

<jats:title>Location matters for immunosuppression</jats:title> <jats:p> In the gut, food antigens and resident microbes can trigger unwanted immune responses. Immunosuppressive cell types in the gut, such as regulatory T cells (T <jats:sub>regs</jats:sub> ) and intraepithelial T lymphocytes (IELs), help to keep these responses at bay. Sujino et al. report that the specific anatomical location within the gut shapes the properties of the suppressive T cell populations that reside there (see the Perspective by Colonna and Cervantes-Barragan). Using mice, they find that T <jats:sub>regs</jats:sub> primarily reside in the lamina propria. T <jats:sub>regs</jats:sub> migrate to the intestinal epithelium, where they convert to IELs in a process that depends on the microbiota and the loss of a specific transcription factor. T <jats:sub>regs</jats:sub> and IELs also play distinct but complementary roles in suppressing intestinal inflammation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6293" page="1581" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf3892">1581</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6293" page="1515" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aag1719">1515</jats:related-article> </jats:p>

<jats:title>Single-nucleus gene expression</jats:title> <jats:p> Identifying the genes expressed at the level of a single cell nucleus can better help us understand the human brain. Blue <jats:italic>et al.</jats:italic> developed a single-nuclei sequencing technique, which they applied to cells in classically defined Brodmann areas from a postmortem brain. Clustering of gene expression showed concordance with the area of origin and defining 16 neuronal subtypes. Both excitatory and inhibitory neuronal subtypes show regional variations that define distinct cortical areas and exhibit how gene expression clusters may distinguish between distinct cortical areas. This method opens the door to widespread sampling of the genes expressed in a diseased brain and other tissues of interest. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6293" page="1586" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf1204">1586</jats:related-article> </jats:p>

<jats:title>Making error-free DNA from RNA</jats:title> <jats:p> DNA polymerase enzymes copy DNA into new strands of identical DNA. Reverse transcriptase (RT) enzymes copy RNA into DNA. Unlike many DNA polymerases, RT enzymes do not have a proofreading function that checks for errors in the newly synthesized DNA. Ellefson <jats:italic>et al.</jats:italic> use in vitro directed evolution and protein engineering to build an error-correcting RT from a prokaryotic DNA polymerase. The RT “xenopolymerase” shows increased fidelity as compared to natural RTs and should streamline and increase the precision of transcriptomics methods. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6293" page="1590" related-article-type="in-this-issue" vol="352" xlink:href="10.1126/science.aaf5409">1590</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>