Catálogo de publicaciones - revistas

<jats:title>No turning back?</jats:title> <jats:p> Ecosystems over time have endured much disturbance, yet they tend to remain intact, a characteristic we call resilience. Though many systems have been lost and destroyed, for systems that remain physically intact, there is debate as to whether changing temperatures will result in shifts or collapses. Wernburg <jats:italic>et al.</jats:italic> show that extreme warming of a temperate kelp forest off Australia resulted not only in its collapse, but also in a shift in community composition that brought about an increase in herbivorous tropical fishes that prevent the reestablishment of kelp. Thus, many systems may not be resilient to the rapid climate change that we face. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6295" page="169" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aad8745">169</jats:related-article> </jats:p>

<jats:title>Env's transmembrane domain revealed</jats:title> <jats:p> HIV-1's envelope protein (Env) spans the viral membrane and grants the virus entry into host cells. Env is also the sole protein of HIV-1 that is targeted by antibodies, making it a key target for vaccine design. Dev <jats:italic>et al.</jats:italic> used nuclear magnetic resonance to determine an atomic-level structure of the membrane-spanning region of Env in a lipid bicelle. Env's transmembrane domain forms a well-ordered trimer, which includes a stabilizing C-terminal hydrophilic core. Disrupting this core alters the sensitivity of Env to broadly neutralizing antibodies, suggesting the potential importance of this region to vaccine design. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6295" page="172" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf7066">172</jats:related-article> </jats:p>

<jats:title>Going with the flow</jats:title> <jats:p> The interstitial spaces of the brain are filled with cerebrospinal fluid (CSF). Faubel <jats:italic>et al.</jats:italic> studied fluid transport in the third ventricle of the brain of mice, rats, and pigs. Sophisticated, state-of-the-art fluid dynamic studies revealed a complex pattern of cilia beating that leads to an intricate network of “highways” of CSF flow. This flow rapidly and efficiently transports and partitions CSF. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6295" page="176" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aae0450">176</jats:related-article> </jats:p>

<jats:title>Engineering T cells to treat autoimmunity</jats:title> <jats:p> Autoimmune diseases such as lupus and rheumatoid arthritis lack therapies that specifically target only the disease-causing cells. Inspired by the clinical success of using chimeric antigen receptor T cells to treat certain types of cancers, Ellebrecht <jats:italic>et al.</jats:italic> asked whether a similar approach might also work against antibody-driven autoimmune diseases. They engineered T cells to express chimeric receptors consisting of the disease-causing autoantigen desmoglein 3 fused to signaling domains that activate T cells. When given to diseased mice, the engineered T cells targeted and killed B cells that express antibodies targeting desmoglein 3, hinting that such a strategy may be an effective way to treat antibody-driven autoimmune diseases. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6295" page="179" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf6756">179</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>