Catálogo de publicaciones - revistas

<jats:title>Next steps toward curing HIV-1</jats:title> <jats:p> Since the discovery of HIV-1 more than 30 years ago, prevention and treatment strategies have dominated the research agenda. More recently, however, scientists are also focusing their efforts toward finding a cure. Margolis <jats:italic>et al.</jats:italic> review an approach that involves HIV-1 latency reversal and viral clearance. The idea is to reactivate any dormant virus and coax it to produce viral proteins that the immune system can recognize. By combining a latency reversal strategy with immunotherapies, the body might be able to rid itself of all infected cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/353/6297/362.full">362</jats:ext-link> </jats:p>

<jats:title>Building a computing system in bacteria</jats:title> <jats:p> Finite state machines are logic circuits with a predetermined sequence of actions that are triggered depending on the starting conditions. They are used for a variety of devices and biological systems, from vending machines to neural circuits. Roquet <jats:italic>et al.</jats:italic> have taken a finite state machine approach to control the expression of integrases, or enzymes that insert or excise phage DNA into or out of bacterial chromosomes. The integrases altered the DNA sequence of a plasmid to record all five possible combinations of two inputs. Such circuits can be used to record the states that the cell experienced over time and can be deployed in state-dependent gene expression programs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/353/6297/363.full">363</jats:ext-link> </jats:p>

<jats:p>On 23 July, exactly 1 month after Britain's momentous decision to leave the European Union, around 4500 scientists and friends of science will assemble in Manchester, UK, for the opening of the EuroScience Open Forum (ESOF), Europe's largest interdisciplinary research conference. The vote for Britain's exit (“Brexit”)—with worrying repercussions for European science and wider society—and questions about the plans of the new UK Prime Minister Theresa May, will inevitably cast a shadow over proceedings. But as Jerzy Langer, chair of ESOF's program committee, argues, the meeting has now acquired a sharper purpose: to demonstrate at a time of acute uncertainty that “we, the scientists, are one big family, whose rules and values extend beyond political and geographic borders.”</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Unusual bacteria in vagina help explain high infection rates in South African women.</jats:p>

<jats:p>Major charities back creation of Africa Health Research Institute to tackle South African epidemics.</jats:p>

<jats:p>Controversial proposal envisions the construction of a massive, predator-free pen.</jats:p>

<jats:p>Clashes between the cell's two genomes—mitochondrial and nuclear—could shape the tree of life.</jats:p>

<jats:p>Honeyguides understand specific human signal.</jats:p>