Catálogo de publicaciones - revistas

<jats:title>Show me a sign of sweetness to come</jats:title> <jats:p> Communication between humans and domesticated animals is common. Regular communication between humans and wild animals, however, is rare. African honey-guide birds are known to regularly lead human honey-hunters to bee colonies, and the humans, on opening up the nest, leave enough mess for the birds to feast on. Spottiswoode <jats:italic>et al.</jats:italic> show that when the honey-hunters make a specific call, honey-guides are both more likely to come to their aid and more likely to find them a bee's nest. This interaction suggests that the birds are able to attach a specific meaning of cooperation to the human's call—a rare case of mutualism between humans and a wild animal. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6297" page="387" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf4885">387</jats:related-article> </jats:p>

<jats:title>Designed to assemble</jats:title> <jats:p> Symmetric macromolecular structures that form cages, such as viral capsids, have inspired protein engineering. Bale <jats:italic>et al.</jats:italic> used pairwise combinations of dimeric, trimeric, or pentameric building blocks to design two-component, 120-subunit protein complexes with three distinct icosahedral architectures. The capsid-like nanostructures are large enough to hold nucleic acids or other proteins, and because they have two components, the assembly of cargoes such as drugs and vaccines can be done in a controlled way. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6297" page="389" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf8818">389</jats:related-article> </jats:p>

<jats:title>Eliminating paternal mitochondria</jats:title> <jats:p> During fertilization, the oocyte and sperm each bring their mitochondria to the union. Shortly afterward, the paternal mitochondria are degraded, and only the maternal mitochondria are conveyed to the progeny. Zhou <jats:italic>et al.</jats:italic> observed that the integrity of the inner membrane of paternal mitochondria is compromised, which apparently marks them for degradation (see the Perspective by van der Bliek). Autophagy commences by mitochondrial endonuclease G relocating from the intermembrane space into the matrix and subsequently degrading the paternal mitochondrial DNA. Any delay in this process increases embryonic lethality. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6297" page="394" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf4777">394</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6297" page="351" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aah4131">351</jats:related-article> </jats:p>

<jats:title>Cyclin suppresses antitumor immunity</jats:title> <jats:p> Despite the dramatic success of cancer immunotherapy, many types of cancer do not respond. Understanding why could help us to find ways to enhance the overall responsiveness of tumors to immunotherapies. Dorand <jats:italic>et al.</jats:italic> report that cyclin-dependent kinase 5 (Cdk5), an enzyme that is highly expressed by neurons in many brain cancers, may dampen the ability of T cells to reject tumors. In a mouse model of medulloblastoma, if tumors were Cdk5 deficient, T cells were able to remove them. This heightened antitumor immunity correlated with reduced expression of the inhibitory molecule programmed cell death ligand 1 (PD-L1), a target of current cancer immunotherapies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6297" page="399" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aae0477">399</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>