Catálogo de publicaciones - revistas

<jats:title>Delivering chlorine to those who use it</jats:title> <jats:p> In developed countries, a consumer's valuation of a health product can be measured by his or her willingness to pay for it. But poorer individuals, especially those in developing countries, might want and need a product yet be unable to pay for it with money. Dupas <jats:italic>et al.</jats:italic> demonstrate that a nonprice voucher mechanism can be used to deliver chlorine for water treatment to people in Kenya who are too poor to pay for it, but who use it when they get it (see the Perspective by Olken). Having to redeem the vouchers screens out people who would accept the free chlorine solution but not use it. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6302" page="889" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aaf6288">889</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6302" page="864" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aah5055">864</jats:related-article> </jats:p>

<jats:title>How spliceosomes make the first cut</jats:title> <jats:p> In eukaryotes, transcribed precursor mRNA includes noncoding sequences that must be spliced out. This is done by the spliceosome, a dynamic complex in which five small nuclear RNAs and several proteins go through a series of ordered interactions and conformational rearrangements to achieve splicing. Two protein structures provide a look at the first catalytic step in the pathway. Yan <jats:italic>et al.</jats:italic> report the structure of the activated spliceosome (the B <jats:sup>act</jats:sup> complex) at 3.5 Å resolution, revealing how latency is maintained even though the complex is mostly primed for catalysis. Wan <jats:italic>et al.</jats:italic> report the structure of the catalytic step 1 spliceosome (the C complex) at 3.4 Å resolution; this complex forms after the first step of the splicing reaction. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue pp. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6302" page="904" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aag0291">904</jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6302" page="895" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aag2235">895</jats:related-article> </jats:p>

<jats:title>How spliceosomes make the first cut</jats:title> <jats:p> In eukaryotes, transcribed precursor mRNA includes noncoding sequences that must be spliced out. This is done by the spliceosome, a dynamic complex in which five small nuclear RNAs and several proteins go through a series of ordered interactions and conformational rearrangements to achieve splicing. Two protein structures provide a look at the first catalytic step in the pathway. Yan <jats:italic>et al.</jats:italic> report the structure of the activated spliceosome (the B <jats:sup>act</jats:sup> complex) at 3.5 Å resolution, revealing how latency is maintained even though the complex is mostly primed for catalysis. Wan <jats:italic>et al.</jats:italic> report the structure of the catalytic step 1 spliceosome (the C complex) at 3.4 Å resolution; this complex forms after the first step of the splicing reaction. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue pp. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6302" page="904" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aag0291">904</jats:related-article> and <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6302" page="895" related-article-type="in-this-issue" vol="353" xlink:href="10.1126/science.aag2235">895</jats:related-article> </jats:p>