Catálogo de publicaciones - revistas

<jats:title>Delivering health care to mystery patients</jats:title> <jats:p> Many families in developing countries do not have access to medical doctors and instead receive health care from informal providers. Das <jats:italic>et al.</jats:italic> used “mystery” patients (trained actors) to test whether a 9-month training program improved the quality of care delivered by informal providers in West Bengal (see the Perspective by Powell-Jackson). The patients did not identify themselves to the providers and were not told which providers had participated in the training program. The results of this blinded assessment showed that medical doctors delivered better care than informal providers but that the training program closed much of the gap. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/354/6308/aaf7384.full">80</jats:ext-link> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6308" page="34" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aai8652">34</jats:related-article> </jats:p>

<jats:title>Building the human brain</jats:title> <jats:p> As the brain develops, neurons migrate from zones of proliferation to their final locations, where they begin to build circuits. Paredes <jats:italic>et al.</jats:italic> have discovered that shortly after birth, a group of neurons that proliferates near the ventricles migrates in chains alongside circulatory vessels into the frontal lobes (see the Perspective by McKenzie and Fishell). Young neurons that migrate postnatally into the anterior cingulate cortex then develop features of inhibitory interneurons. The number of migratory cells decreases over the first 7 months of life, and by 2 years of age, migratory cells are not evident. Any damage during migration, such as hypoxia, may affect the child's subsequent physical and behavioral development. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/354/6308/aaf7073.full">81</jats:ext-link> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6308" page="38" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aai9379">38</jats:related-article> </jats:p>

<jats:title>DNA damage-activated nuclease identified</jats:title> <jats:p> Cells that experience stresses and accumulate excessive damage to DNA undergo cell death mediated by a nuclear enzyme known as PARP-1. During this process, apoptosis-inducing factor (AIF) translocates to the nucleus and activates one or more nucleases to cleave DNA. Wang <jats:italic>et al.</jats:italic> found that macrophage migration inhibitory factor (MIF) is an AIF-associated endonuclease that contributes to PARP-1-induced DNA fragmentation (see the Perspective by Jonas). In mouse neurons in culture, loss of MIF protected neurons from cell death caused by excessive stimulation. Targeting MIF could thus provide a therapeutic strategy against diseases in which PARP-1 activation is excessive. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/content/354/6308/aad6872.full">82</jats:ext-link> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6308" page="36" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aai8756">36</jats:related-article> </jats:p>