Catálogo de publicaciones - revistas

<jats:title>Digital reconstruction of human development</jats:title><jats:p>The detailed morphology of human development has intrigued scientists and the medical field alike. However, the scarcity of specimens hampers detailed mapping of tissue architecture. Furthermore, inaccuracies in the description of human development have crept into textbooks from observations of animal models that are extrapolated to humans. By mapping normal developmental processes and patterns, such as the growth and relative placement of organs, congenital anomalies can be better understood. de Bakker<jats:italic>et al.</jats:italic>generated interactive three-dimensional digital reconstructions based on the Carnegie collection of histologically sectioned human embryos spanning the first 2 months of gestation. These interactive models will serve as educational and scientific resources for normal and abnormal human development.</jats:p><jats:p><jats:italic>Science</jats:italic>, this issue p.<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aag0053">10.1126/science.aag0053</jats:related-article></jats:p>

<jats:title>For cell reprogramming, context matters</jats:title> <jats:p> Differentiated cells in a culture dish can assume a new identity when manipulated to express four transcription factors. This “reprogramming” process has sparked interest because conceivably it could be harnessed as a therapeutic strategy for tissue regeneration. Mosteiro <jats:italic>et al.</jats:italic> used a mouse model to study the signals that promote cell reprogramming in vivo. They found that the factors that trigger reprogramming in vitro do the same in vivo; however, they also inflict cell damage. The damaged cells enter a state of senescence and begin secreting certain factors that promote reprogramming, including an inflammatory cytokine called interleukin-6. Thus, in the physiological setting, cell senescence may create a tissue context that favors reprogramming of neighboring cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaf4445">10.1126/science.aaf4445</jats:related-article> </jats:p>

<jats:p>Faced with the uncertainty of what the 2016 U.S. presidential election means for science, we may find some reassurance in understanding that the health of the nation's scientific enterprise depends on much more than the attitudes of the particular person who is president. We must not forget that members of Congress and other national, state, local, and international officials also make policy and collectively constitute a considerable force that is in many ways more influential than the president alone. There is now important work to do ensuring that all citizenry, including the president, understand the powerful benefits of science and that decisions made with scientific input are more likely to succeed.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Seldom-used law will give Trump, Congress free rein to cancel scores of recent rules.</jats:p>

<jats:p>Shifting gas mix warns that magma is on the rise.</jats:p>

<jats:p>5000-year-old Mexican cobs offer a detailed genetic snapshot of the partly domesticated grain.</jats:p>