Catálogo de publicaciones - revistas

<jats:title>Beating the curse of the parasite</jats:title> <jats:p> The evolution of molecular replicators was a critical step in the origin of life. Such replicators would have suffered from faster-replicating “molecular parasites” outcompeting the parental replicator. Compartmentalization of replicators inside protocells would have helped ameliorate the effect of parasites. Matsumura <jats:italic>et al.</jats:italic> show that transient compartmentalization in nonbiological materials is sufficient to tame the problem of parasite takeover. They analyzed viral replication in a droplet-based microfluidic system, which revealed that as long as there is selection for a functional replicator, the population is not overwhelmed by the faster-replicating parasite genomes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6317" page="1293" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aag1582">1293</jats:related-article> </jats:p>

<jats:title>Engineering cells to regulate glucose</jats:title> <jats:p> Diabetes mellitus affects hundreds of millions of people worldwide. Blood glucose levels are chronically deregulated in diabetics, and this can lead to many serious disorders, including cardiovascular disease and renal failure. Xie <jats:italic>et al.</jats:italic> engineered a synthetic circuit into human cells that can sense the glucose concentration and respond to correct deregulation. Implants containing designer cells improved glucose regulation in diabetic mice. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6317" page="1296" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aaf4006">1296</jats:related-article> </jats:p>

<jats:title>A laboratory model of viral speciation</jats:title> <jats:p> New species arise through the evolution of barriers to reproduction. This process is well understood where the emerging species are spatially isolated from one another. But the process of sympatric speciation—where the diverging species co-occur—is more enigmatic. Bacterial viruses make good models for addressing such questions because of their rapid generation times. Meyer <jats:italic>et al.</jats:italic> took bacteriophage λ and grew it on a mix of two strains of <jats:italic>Escherichia coli.</jats:italic> The virus duly split its host preferences into lineages with differing affinity for their respective <jats:italic>E. coli</jats:italic> hosts. In some experiments, the phages diverged to the extent that they became reproductively restricted to one strain of <jats:italic>E. coli</jats:italic> , even when the other was present. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6317" page="1301" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aai8446">1301</jats:related-article> </jats:p>

<jats:title>Mapping genetic adaptations to pollution</jats:title> <jats:p> Many organisms have evolved tolerance to natural and human-generated toxins. Reid <jats:italic>et al.</jats:italic> performed a genomic analysis of killifish, geographically separate and independent populations of which have adapted recently to severe pollution (see the Perspective by Tobler and Culumber). Sequencing multiple sensitive and resistant populations revealed signals of selective sweeps for variants that may confer tolerance to toxins, some of which were shared between resistant populations. Thus, high genetic diversity in killifish seems to allow selection to act on existing variation, driving rapid adaptation to selective forces such as pollution. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6317" page="1305" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aah4993">1305</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6317" page="1232" related-article-type="in-this-issue" vol="354" xlink:href="10.1126/science.aal3211">1232</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>