Catálogo de publicaciones - revistas

<jats:title>Emergent attitudes toward brilliance</jats:title> <jats:p> The distribution of women and men across academic disciplines seems to be affected by perceptions of intellectual brilliance. Bian <jats:italic>et al.</jats:italic> studied young children to assess when those differential perceptions emerge. At age 5, children seemed not to differentiate between boys and girls in expectations of “really, really smart”—childhood's version of adult brilliance. But by age 6, girls were prepared to lump more boys into the “really, really smart” category and to steer themselves away from games intended for the “really, really smart.” </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="389" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aah6524">389</jats:related-article> </jats:p>

<jats:title>Looking for lost flavor in tomatoes</jats:title> <jats:p> Commercially available tomatoes are renowned these days for sturdiness, but perhaps not for flavor. Heirloom varieties, on the other hand, maintain the richer flavors and sweeter tomatoes of years past. Tieman <jats:italic>et al.</jats:italic> combined tasting panels with chemical and genomic analyses of nearly 400 varieties of tomatoes. They identified some of the flavorful components that have been lost over time. Identification of the genes that have also gone missing provides a path forward for reinstating flavor to commercially grown tomatoes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="391" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal1556">391</jats:related-article> </jats:p>

<jats:title>A rare ability to enhance dengue virus disease</jats:title> <jats:p> In some cases, secondary infections of dengue virus can be extremely serious and result in plasma leakage, thrombocytopenia, and hemorrhagic disease. This phenomenon has been attributed to antibody-dependent enhancement. Wang <jats:italic>et al.</jats:italic> show that a specific subclass of antibody, IgG1, which lacks fucosyl residues on the Fc segment of the heavy chain of the immunoglobulin, is elevated in patients with severe secondary dengue disease. These non-neutralizing antibodies bind activating Fc receptors and appear to cross-react with platelet antigens to cause platelet depletion, contributing to thrombocytopenia. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="395" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aai8128">395</jats:related-article> </jats:p>

<jats:title>Unrelated memories get blurred together</jats:title> <jats:p> If one retrieves two memories around the same time, a small number of neurons will become involved in both memories. Yokose <jats:italic>et al.</jats:italic> investigated the cellular ensemble mechanisms underlying the association between two such memories. In mice, a small population of neurons mediates the association. Memory traces for two independent emotional memories in the brain partially overlapped when the two memories were retrieved synchronously to create a linkage. Suppressing the activity of the overlapping memory trace interrupted the linkage without damaging the original memories. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="398" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal2690">398</jats:related-article> </jats:p>

<jats:title>Proteasomes and SUMO wrestle chromosomes</jats:title> <jats:p> Meiosis is the double cell division that generates haploid gametes from diploid parental cells. Pairing of homologous chromosomes during the first meiotic division ensures that each gamete receives a complete set of chromosomes. The proteasome, on the other hand, is a molecular machine that degrades proteins tagged for destruction within the cell (see the Perspective by Zetka). Ahuja <jats:italic>et al.</jats:italic> show that the proteasome is also involved in ensuring that homologous chromosomes pair with each other during meiosis. Rao <jats:italic>et al.</jats:italic> show that the SUMO (small ubiquitin-like modifier) protein, ubiquitin, and the proteasome localize to the axes between homologous chromosomes. In this location, they help mediate chromosome pairing and recombination between homologs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="349" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aam5904">349</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="408" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aaf4778">408</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="403" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aaf6407">403</jats:related-article> </jats:p>

<jats:title>Proteasomes and SUMO wrestle chromosomes</jats:title> <jats:p> Meiosis is the double cell division that generates haploid gametes from diploid parental cells. Pairing of homologous chromosomes during the first meiotic division ensures that each gamete receives a complete set of chromosomes. The proteasome, on the other hand, is a molecular machine that degrades proteins tagged for destruction within the cell (see the Perspective by Zetka). Ahuja <jats:italic>et al.</jats:italic> show that the proteasome is also involved in ensuring that homologous chromosomes pair with each other during meiosis. Rao <jats:italic>et al.</jats:italic> show that the SUMO (small ubiquitin-like modifier) protein, ubiquitin, and the proteasome localize to the axes between homologous chromosomes. In this location, they help mediate chromosome pairing and recombination between homologs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="349" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aam5904">349</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="408" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aaf4778">408</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="403" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aaf6407">403</jats:related-article> </jats:p>

<jats:title>Pulling macromolecules apart</jats:title> <jats:p> Many biological processes involve macromolecular interactions, and knowing the binding energies of these interactions is key to a functional understanding. There are several experimental approaches to calculate binding energies in bulk solutions, but these require that the binding is at equilibrium. Bulk measurements may also mask different binding modes or concerted binding by several subunits. Camunas-Soler <jats:italic>et al.</jats:italic> used a fluctuation theorem for binding reactions to extract ligand binding energies directly from force experiments that probed a single binding reaction. They resolved binding energies of peptides to specific and non-specific DNA binding sites with affinities spanning six orders of magnitude. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="412" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aah4077">412</jats:related-article> </jats:p>

<jats:title>The platform for building new chromatin</jats:title> <jats:p> Nucleosomes removed from DNA to facilitate its replication must be replaced quickly to protect the genome. The epigenetic information stored on the parental nucleosomes must also be preserved on the daughter DNA strands. The replication protein A complex (RPA) is a critical component of the DNA replication machinery. RPA binds single-stranded DNA. Liu <jats:italic>et al.</jats:italic> show that RPA bound to a single-stranded DNA replication fork mimic recruits and promotes the assembly of H3-H4 histone tetramers onto adjacent double-stranded DNA. It also recruits specific H3-H4 chaperones, which facilitate the assembly of new nucleosomes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6323" page="415" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aah4712">415</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> In the life sciences, experimental reproducibility and repeatability are essential for ensuring that the results obtained are real and trustworthy. This often involves running an experiment multiple times under identical conditions. When repeating experiments, variation introduced through human error, environmental changes, or technical fluctuations can negatively impact the data and cause the generation of spurious results. For example, when imaging cells, slight shifts in temperature, CO <jats:sub>2</jats:sub> levels, or light conditions can dramatically affect the data. The automation of methodologies, in concert with the ability to run multiple experiments in parallel, can go a long way to solving this problem. During this webinar we will provide examples of how automation of imaging methods can save time and money, making your work easier and more efficient and enabling the generation of more reliable data. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://webinar.sciencemag.org/webinar/archive/what-automation-can-do-you-benefits-and-pitfalls-automating-your-microscopy-research">View the Webinar</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>