Catálogo de publicaciones - revistas

<jats:title>A framework for molecular assembly</jats:title> <jats:p>Covalent molecular frameworks are crystalline microporous materials assembled from organic molecules through strong covalent bonds in a process termed reticular synthesis. Diercks and Yaghi review developments in this area, noting the parallels between framework assembly and the covalent assembly of atoms into molecules, as described just over a century ago by Lewis. Emerging challenges include functionalization of existing frameworks and the creation of flexible materials through the design of woven structures.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6328" page="eaal1585" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal1585">eaal1585</jats:related-article> </jats:p>

<jats:title>Navigating regulated cell excitation</jats:title> <jats:p> Voltage-gated sodium (Na <jats:sub>v</jats:sub> ) channels respond to a change in voltage potential by allowing sodium ions to move into cells, thus initiating electrical signaling. Mutations in Na <jats:sub>v</jats:sub> channels cause neurological and cardiovascular disorders, making the channels important therapeutic targets. Shen <jats:italic>et al.</jats:italic> determined a high-resolution structure of a Na <jats:sub>v</jats:sub> channel from the American cockroach by electron microscopy. The structure affords insight into voltage sensing and ion permeability and provides a foundation for understanding function and disease mechanism of Na <jats:sub>v</jats:sub> and the related Ca <jats:sub>v</jats:sub> ion channels. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6328" page="eaal4326" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal4326">eaal4326</jats:related-article> </jats:p>

<jats:p>Albert Schweitzer, physician and Nobel laureate, wrote: “The first step in the evolution of ethics is a sense of solidarity with other human beings.” The evolution of U.S. policy governing heritable human germline modification reflects this observation, and a “Human Genome Editing” consensus study committee of the U.S. National Academy of Sciences and National Academy of Medicine (NAM) concluded last month that clinical trials for heritable editing, under strict regulations, may eventually be permissible for parents hoping to prevent serious diseases in their children.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Radio dishes in Chile and Antarctica put event horizon of Milky Way's behemoth in reach.</jats:p>

<jats:p>Project would read genomes of more than a million eukaryotes—just for starters.</jats:p>

<jats:p>Border clampdown could disrupt web of collaborations.</jats:p>

<jats:p>Data could help point to perpetrators in aftermath.</jats:p>