Catálogo de publicaciones - revistas

<jats:p> We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified <jats:italic>Saccharomyces cerevisiae</jats:italic> genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered. Sc2.0 chromosome design was implemented with BioStudio, an open-source framework developed for eukaryotic genome design, which coordinates design modifications from nucleotide to genome scales and enforces version control to systematically track edits. To achieve complete Sc2.0 genome synthesis, individual synthetic chromosomes built by Sc2.0 Consortium teams around the world will be consolidated into a single strain by “endoreduplication intercross.” Chemically synthesized genomes like Sc2.0 are fully customizable and allow experimentalists to ask otherwise intractable questions about chromosome structure, function, and evolution with a bottom-up design strategy. </jats:p>

<jats:title>Start with the transition state</jats:title> <jats:p> Zeolites catalyze a wide range of industrial reactions, but identifying the reactions that they catalyze well tends to be done by trial and error. Gallego <jats:italic>et al.</jats:italic> propose a way to rationalize the process by using structure-directing agents that act as scaffolds for creating the zeolite pores and channels (see the Perspective by Millini). They picked molecules that mimic the transition states for reactions such as the isomerization of ethylbenzene into xylene, and they successfully identified catalysts with improved reactant conversion and product selectivity. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6329" page="1051" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal0121">1051</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6329" page="1028" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aam8037">1028</jats:related-article> </jats:p>

<jats:title>Bone-inspired steel</jats:title> <jats:p> Load cycling of metal components leads to fatigue and ultimately failure through the propagation of cracks. Koyama <jats:italic>et al.</jats:italic> took inspiration from bone to develop a steel with a laminated substructure that arrests cracks. The resulting hierarchical material has much better fatigue resistance properties than other iron alloys. The strategy need not be limited to steel; other metal alloys should also benefit from this type of microstructural engineering. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6329" page="1055" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal2766">1055</jats:related-article> </jats:p>

<jats:title>Doped photonics</jats:title> <jats:p> Doping semiconductor materials with impurity atoms enables control of the optoelectronic properties that enhance functionality. Liberal <jats:italic>et al.</jats:italic> describe numerically and experimentally an analogous doping effect for a group of photonic materials. They introduced a dielectric into an otherwise nonmagnetic material, which produced a magnetic response. The generality of the method should allow the design of photonic materials with enhanced and controlled electromagnetic response. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6329" page="1058" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal2672">1058</jats:related-article> </jats:p>