Catálogo de publicaciones - revistas

<jats:title>Uridine's rise and fall: Food for thought</jats:title> <jats:p> The nucleoside uridine is well known for its role in critical cellular functions such as nucleic acid synthesis. Its role in whole-animal physiology has received comparatively little attention. In mammals, plasma uridine levels are tightly regulated, but the underlying mechanisms are unclear. Studying mouse models, Deng <jats:italic>et al.</jats:italic> show that plasma uridine levels are controlled by feeding behavior (see the Perspective by Jastroch and Tschöp). Fasting causes an adipocyte-mediated rise in plasma uridine, which triggers a lowering of body temperature. Feeding causes a bile-mediated drop in plasma uridine, which enhances insulin sensitivity in a leptin-dependent manner. Thus, uridine is part of a complex regulatory loop that affects energy balance and potentially contributes to metabolic disease. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article issue="6330" page="aaf5375" related-article-type="in-this-issue" vol="355">aaf5375</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6330" page="1124" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aan0825">1124</jats:related-article> </jats:p>

<jats:title>The lights go on in order</jats:title> <jats:p> Grid cells and place cells in the brain function as part of a circuit that helps us figure out where we are in our physical world. Donato <jats:italic>et al.</jats:italic> examined how that circuit develops in the brains of mice. Expression patterns of doublecortin and parvalbumin revealed that neurons in the circuit mature in the order in which information flows. Maturation of each piece of the circuit depends on excitatory neuronal activity from the preceding portion. Stellate cells, in contrast, follow an endogenous maturation program. The stellate cells are responsible for initiating the circuit's developmental progression. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6330" page="eaai8178" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aai8178">eaai8178</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Epigenetic modifications to DNA and histone proteins are known to regulate metabolic gene expression, which in turn impacts metabolite levels. Conversely, the machinery responsible for modifying DNA and histones at the epigenetic level is highly sensitive to metabolites arising from cellular metabolism. Thus, the metabolic changes associated with oncogenesis may affect the epigenetic machinery, creating a feedback loop that synergistically promotes the progression of cancer. This webinar will examine how, by targeting proteins responsible for the crosstalk between epigenetics and metabolism, we may be able to develop new and effective therapeutic options for cancer treatment.</jats:p> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/custom-publishing/webinars/deciphering-cancer-intersection-epigenetics-metabolism-and-tumorigenesis">View the Webinar</jats:ext-link> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>Epigenetic modifications to DNA and histone proteins are known to regulate metabolic gene expression, which in turn impacts metabolite levels. Conversely, the machinery responsible for modifying DNA and histones at the epigenetic level is highly sensitive to metabolites arising from cellular metabolism. Thus, the metabolic changes associated with oncogenesis may affect the epigenetic machinery, creating a feedback loop that synergistically promotes the progression of cancer. This webinar will examine how, by targeting proteins responsible for the crosstalk between epigenetics and metabolism, we may be able to develop new and effective therapeutic options for cancer treatment.</jats:p> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/custom-publishing/webinars/deciphering-cancer-intersection-epigenetics-metabolism-and-tumorigenesis">View the Webinar</jats:ext-link> </jats:p>

<jats:p>Cancer is increasingly being viewed as an ecosystem, a community in which tumor cells cooperate with other tumor cells and host cells in their microenvironment. As conditions change, the ecosystem evolves and adapts to ensure the survival and growth of cancer. Our understanding of the intricate relationships in this ecosystem has led to revolutionary treatments, including immunotherapy. Successful treatment and prevention of cancer require an ecosystem, too—a coordinated unit of researchers, patients, health care professionals, health care systems, regulatory agencies, government, and industry. How can these partners work together as one interconnected community?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>