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<jats:title>Added complexity in an asymmetric receptor</jats:title> <jats:p> <jats:italic>N</jats:italic> -methyl- <jats:sc>d</jats:sc> -aspartate receptors (NMDARs) are heterotetrameric ion channels that initiate chemical and electrical signals in postsynaptic cells. They play key roles in brain development and function and are the targets of drugs for treating neurological disorders such as schizophrenia, depression, and epilepsy. For the channel to open, it must bind glutamate and glycine and release a blocking magnesium ion. Most NMDARs have three different subunits that bind glycine and glutamine, but structural studies have focused on tetramers of only two subunits. Lü <jats:italic>et al.</jats:italic> determined the structure of triheteromeric NMDAR. The structural studies show how having three different subunits modifies receptor symmetry and subunit interactions and increases the complexity of receptor regulation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6331" page="eaal3729" related-article-type="in-this-issue" vol="355" xlink:href="10.1126/science.aal3729">eaal3729</jats:related-article> </jats:p>

<jats:p>Nine months since the British vote to exit the European Union (“Brexit”), the UK science community's initial dismay has given way to hard-boiled determination to limit the damage it will do to universities and research. On 29 March, Prime Minister Theresa May is expected to give formal notification of the UK's intention to withdraw under Article 50 of the Lisbon Treaty, the constitutional basis of the EU. This will set in motion a 2-year period of intense negotiation on the terms of the UK's divorce, and any future agreements with the EU—with research just one line item on a long list of issues to be resolved.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Drastic cuts meet strong resistance from Congress, community.</jats:p>

<jats:p>Two trials test whether influenza vaccinations make the body more accepting of IVF embryos.</jats:p>

<jats:p>New analysis of fossil traits shuffles dinosaur family tree.</jats:p>

<jats:p>Fault-jumping behavior in magnitude-7.8, 2016 earthquake shows that chances of Big Ones elsewhere may be higher.</jats:p>

<jats:p>U.S. Energy Department mulls probe of shadow world.</jats:p>

<jats:p>Improved targeting could upset strategic balance with Russia and spur arms race.</jats:p>

<jats:p>Accusations of research fraud roil a tight-knit community of ecologists.</jats:p>