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Science

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

Brian M. CastellanoORCID; Ashley M. ThelenORCID; Ofer Moldavski; McKenna FeltesORCID; Reini E. N. van der Welle; Laurel Mydock-McGraneORCID; Xuntian Jiang; Robert J van EijkerenORCID; Oliver B. Davis; Sharon M. LouieORCID; Rushika M. Perera; Douglas F. CoveyORCID; Daniel K. Nomura; Daniel S. Ory; Roberto ZoncuORCID

<jats:p>A cholesterol-mTORC1 axis may play a role in metabolic homeostasis in normal and disease states.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1306-1311

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

Jun LiORCID; Michael S. Bonkowski; Sébastien Moniot; Dapeng Zhang; Basil P. Hubbard; Alvin J. Y. LingORCID; Luis A. RajmanORCID; Bo Qin; Zhenkun Lou; Vera Gorbunova; L. Aravind; Clemens Steegborn; David A. SinclairORCID

<jats:p> NAD <jats:sup>+</jats:sup> can influence DNA repair by modulating protein interactions. </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1312-1317

A macrophage relay for long-distance signaling during postembryonic tissue remodeling

Dae Seok EomORCID; David M. ParichyORCID

<jats:p>Macrophage projections participate in long-range signaling between pigment cells during zebrafish stripe formation.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1317-1320

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

Vincent C. LucaORCID; Byoung Choul Kim; Chenghao GeORCID; Shinako Kakuda; Di WuORCID; Mehdi Roein-Peikar; Robert S. Haltiwanger; Cheng ZhuORCID; Taekjip Ha; K. Christopher GarciaORCID

<jats:p>Forces on Notch receptors can modulate receptor signaling.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1320-1324

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

Eneda ToskaORCID; Hatice U. Osmanbeyoglu; Pau CastelORCID; Carmen ChanORCID; Ronald C. HendricksonORCID; Moshe ElkabetsORCID; Maura N. Dickler; Maurizio ScaltritiORCID; Christina S. LeslieORCID; Scott A. ArmstrongORCID; José BaselgaORCID

<jats:p>Tumor cells develop resistance to a drug used to treat breast cancer through a chromatin remodeling mechanism.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1324-1330

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

Cristian TomasettiORCID; Lu LiORCID; Bert VogelsteinORCID

<jats:p>A substantial fraction of mutations in human cancer are attributable to random errors occurring during DNA replication.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1330-1334

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1335-1335

Learning from rejections

Andy Tay

Palabras clave: Multidisciplinary.

Pp. 1342-1342

When did humans settle down? The house mouse may have the answer

Michael Price

Palabras clave: Multidisciplinary.

Pp. No disponible

Why do the world’s largest trees have some of the smallest leaves?

Katherine Kornei

Palabras clave: Multidisciplinary.

Pp. No disponible