Catálogo de publicaciones - revistas

<jats:title>An earthquake with a dozen faults</jats:title> <jats:p> The 2016 moment magnitude ( <jats:italic>M</jats:italic> <jats:sub>w</jats:sub> ) 7.8 Kaikōura earthquake was one of the largest ever to hit New Zealand. Hamling <jats:italic>et al.</jats:italic> show with a new slip model that it was an incredibly complex event. Unlike most earthquakes, multiple faults ruptured to generate the ground shaking. A remarkable 12 faults ruptured overall, with the rupture jumping between faults located up to 15 km away from each other. The earthquake should motivate rethinking of certain seismic hazard models, which do not presently allow for this unusual complex rupture pattern. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6334" page="eaam7194" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aam7194">eaam7194</jats:related-article> </jats:p>

<jats:title>Stitching one alkyl group to another</jats:title> <jats:p>Chemical reactions such as Heck and Suzuki coupling facilitate access to an enormous range of relatively flat molecules. This geometrical constraint is associated with the comparative ease of linking together aryl and alkenyl carbons. Choi and Fu review recent developments in forming bonds between the more abundant alkyl carbon centers that underlie diverse molecules with complex three-dimensional structures. Nickel catalysis in particular has emerged as a powerful method to access individual mirror-image isomers selectively and thereby tune the biological properties of the targeted products.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6334" page="eaaf7230" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aaf7230">eaaf7230</jats:related-article> </jats:p>

<jats:title>In vitro embryogenesis</jats:title> <jats:p> Pluripotent embryonic stem cells (ESCs) can differentiate into any adult cell type; however, aggregates of these cells do not mimic embryonic architecture when grown in culture. To see whether mouse ESCs and their extraembryonic counterparts, trophoblast stem cells (TSCs), can recapitulate normal development, Harrison <jats:italic>et al.</jats:italic> combined ESCs and TSCs in an extracellular matrix culture (see the Perspective by Pera). The resultant “ETS-embryos” displayed considerable resemblance to normal embryos, even specifying mesoderm and primordial germ cells at the boundary between embryonic and extraembryonic compartments. These ETS-embryos are a genetically tractable tool for studying mammalian embryogenesis. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6334" page="eaal1810" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aal1810">eaal1810</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6334" page="137" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aan1495">137</jats:related-article> </jats:p>

<jats:p> The U.S. public and private sectors invest billions of dollars and countless hours of highly skilled labor into scientific research every year, an investment that delivers enormous benefits to society. Integrity is indispensable to the orderly and efficient progress of this research. Regrettably, there have been some well-publicized breakdowns in scientific integrity and reported cases of irreproducible research. A new report from the U.S. National Academies of Sciences, Engineering, and Medicine (NASEM), <jats:italic>Fostering Integrity in Research</jats:italic> , recommends specific steps to secure a future based on integrity and reliability ( <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.nap.edu/catalog/21896/">www.nap.edu/catalog/21896/</jats:ext-link> ). These include establishing a new Research Integrity Advisory Board (RIAB) and taking stronger actions to discourage and eliminate practices that are clearly detrimental to research. </jats:p>