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Institución detectada	Período	Navegá	Descargá	Solicitá
No detectada	desde mar. 1997 / hasta dic. 2023	Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

1880-

Cobertura temática

Ciencias naturales

Tabla de contenidos

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doi: 10.1126/science.aam9361

Control of muscle formation by the fusogenic micropeptide myomixer

Pengpeng Bi; Andres Ramirez-Martinez; Hui Li; Jessica Cannavino; John R. McAnally; John M. Shelton; Efrain Sánchez-Ortiz; Rhonda Bassel-Duby; Eric N. Olson

<jats:title>Micromanaging muscle cell fusion</jats:title> <jats:p> Adult skeletal muscles are characterized by long, multinucleated cells called myofibers. Myofibers form when muscle precursor cells, or myoblasts, differentiate and fuse together during embryogenesis. The fusion process is not fully understood. Studying cell culture and mouse models, Bi <jats:italic>et al.</jats:italic> identified an 84–amino acid peptide that promotes myoblast fusion. This small peptide, called Myomixer, physically interacts with and stimulates the activity of a fusogenic membrane protein called Myomaker. Notably, the Myomaker-Myomixer pair can also promote the fusion of nonmuscle cells, such as fibroblasts. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6335" page="323" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aam9361">323</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 323-327

doi: 10.1126/science.aai8764

Microtubules acquire resistance from mechanical breakage through intralumenal acetylation

Zhenjie Xu; Laura Schaedel; Didier Portran; Andrea Aguilar; Jérémie Gaillard; M. Peter Marinkovich; Manuel Théry; Maxence V. Nachury

<jats:title>Acetylation keeps microtubules strong</jats:title> <jats:p> Cells need microtubules for intracellular transport and to avoid being crushed. On investigating microtubule breakage in live fibroblasts, Xu <jats:italic>et al.</jats:italic> found that if they were not acetylated, long-lived microtubules underwent frequent rupture after buckling. Acetylation makes microtubules more mechanically stable, facilitates sliding between filaments, and makes the lattice more plastic. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6335" page="328" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aai8764">328</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 328-332

doi: 10.1126/science.356.6335.334

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 334-334

doi: 10.1126/science.356.6335.342