Catálogo de publicaciones - revistas

<jats:title>Germ cells on demand</jats:title> <jats:p> Unlike animals, plants do not set aside a germline. Instead, germ cells are developed on demand from somatic lineages. Zhao <jats:italic>et al.</jats:italic> examined the regulatory pathways that manage the transition from somatic to germ cell development in the small plant <jats:italic>Arabidopsis</jats:italic> (see the Perspective by Vielle-Calzada). The transcription factor WUSCHEL (WUS) was needed early on for development of ovules. Soon after, a trio of inhibitors that work through a cyclin-dependent kinase allowed a transcriptional repressor to down-regulate WUS. This opened the door to meiosis, while restricting the number of reproductive units per seed to one. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6336" page="eaaf6532" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aaf6532">eaaf6532</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6336" page="378" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aan2734">378</jats:related-article> </jats:p>

<jats:title>An old cancer drug's degrading new look</jats:title> <jats:p> Typically, cancer drugs that help only a small number of patients in clinical trials are not pursued. This might change in a future world of precision medicine, where biomarkers will match specific drugs to the patients most likely to respond. Han <jats:italic>et al.</jats:italic> identified the mechanism of action of a cancer drug called indisulam, a sulfonamide tested previously in patients with solid tumors. Indisulam and related sulfonamides killed cells by disrupting precursor mRNA splicing. The drugs targeted a specific RNA splicing factor for degradation by “gluing” it to the CUL4-DCAF15 ubiquitin ligase. Experiments with cancer cell lines suggest that future clinical trials of these drugs should focus on leukemias and lymphomas with high DCAF15 expression levels. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6336" page="eaal3755" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aal3755">eaal3755</jats:related-article> </jats:p>

<jats:title>Single-cell diversity in the brain</jats:title> <jats:p> The cells that make up an organism may all start from one genome, but somatic mutations mean that somewhere along the line of development, an organism's individual cellular genomes diverge. McConnell <jats:italic>et al.</jats:italic> review the implications and causes of single-cell genomic diversity for brain function. Somatic mutations caused by mobile genetic elements or errors in DNA repair may underlie certain neuropsychiatric disorders. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6336" page="eaal1641" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aal1641">eaal1641</jats:related-article> </jats:p>

<jats:p>The Syrian conflict has been described as a new kind of world war: local conflicts with resounding global consequences. It has accelerated the rise of the terrorist group ISIS, destabilized Europe's open border agreement, and led to the single largest refugee crisis in decades. These factors contribute to an emerging fragility that compounds the humanitarian crisis in Syria but also threatens global health.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>As hundreds of thousands joined some 600 gatherings around the globe, local concerns blended with a unifying message of support for science.</jats:p>

<jats:p>Students, researchers, science leaders, and enthusiasts of all stripes turned out, for reasons personal and political.</jats:p>

<jats:p>Startups avoid ITER's path with new prototype reactors.</jats:p>

<jats:p>Skepticism greets report of smashed mastodon bones.</jats:p>