Catálogo de publicaciones - revistas

<jats:title>Blocking somatic genes to make sperm</jats:title> <jats:p> To generate cells with a specific identity, only a subset of genes is used. Most studies focus on factors that turn on cell type–specific gene expression. However, mechanisms are also needed to block expression of genes that specify other cell lineages. Kim <jats:italic>et al.</jats:italic> identified such a mechanism in the <jats:italic>Drosophila</jats:italic> male germ line. A multiple–zinc finger protein and a chromatin remodeler were found to act together to block transcription from cryptic promoters. These factors prevented aberrant gene expression and enabled proper differentiation in the adult sperm stem cell lineage. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6339" page="717" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aal3096">717</jats:related-article> </jats:p>

<jats:title>Neural crest rules the gut</jats:title> <jats:p> The neurons and glial cells that regulate gut function derive from neural crest cells that emerge from the developing neural tube. Lasrado <jats:italic>et al.</jats:italic> used single-cell transcriptomics and mosaic mutagenesis to follow how the enteric nervous system is built in mice. Overlapping expression of regulatory programs supports dynamic determination of cell fates, with the developing neurons organized by clonal lineages. The clonal build model may explain how gut motility is coordinated in sequential segments and gut secretion is coordinated with motility. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6339" page="722" related-article-type="in-this-issue" vol="356" xlink:href="10.1126/science.aam7511">722</jats:related-article> </jats:p>