Catálogo de publicaciones - revistas

<jats:title>Removing orphan proteins from the system</jats:title> <jats:p> The degradation of excess subunits of protein complexes is a major quality-control problem for the cell. How such “orphans” are recognized and tagged for degradation is poorly understood. Two papers identify a protein quality-control pathway that acts on some of the most abundant protein complexes in the human body: hemoglobin and ribosomes (see the Perspective by Hampton and Dargemont). Yanagitani <jats:italic>et al.</jats:italic> show that the central player in this process is an unusual enzyme (UBE2O) that recognizes substrates and tags them for destruction. Other quality-contr ol pathways tend to use separate factors for target selection (often a chaperone), ubiquitin donation (an E2), and ubiquitin conjugati on (an E3). Encoding all three activities in a single factor whose function can be reconstituted in a purified system provides a tractable route to detailed mechanistic and structural dissection. Nguyen <jats:italic>et al.</jats:italic> show the importance of the UBE2O pathway in the differentiation of red blood cells. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6350" page="472" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan0178">472</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6350" page="eaan0218" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan0218">eaan0218</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6350" page="450" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao1896">450</jats:related-article> </jats:p>

<jats:title>In living color</jats:title> <jats:p> Animals live in a colorful world, but we rarely stop to think about how this color is produced and perceived, or how it evolved. Cuthill <jats:italic>et al.</jats:italic> review how color is used for social signals between individual animals and how it affects interactions with parasites, predators, and the physical environment. New approaches are elucidating aspects of animal coloration, from the requirements for complex cognition and perception mechanisms to the evolutionary dynamics surrounding its development and diversification. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6350" page="eaan0221" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan0221">eaan0221</jats:related-article> </jats:p>

<jats:p>In an era of rapid technological change and an increasingly global economy, investments in research and development are crucial for spurring economic growth and sustaining competitiveness. Yet, across the U.S. federal government, scientists are playing a decreasing role in the policymaking that supports this investment, often being pushed out by a political agenda that is stridently antiscience. Meanwhile, Americans are becoming more distrustful of democratic institutions, the scientific method, and basic facts—three core beliefs on which the research enterprise depends. The United States remains the unquestioned global leader in science and innovation, but given a White House that disregards the value of science and an American public that questions the very concept of scientific consensus, sustaining the U.S. commitment to science won't happen without a fight.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>East German records show economic espionage is like R&amp;D “on cocaine” for perpetrators.</jats:p>

<jats:p>More than 400 authors face punishment for peer-review scam.</jats:p>

<jats:p>Improvements in CRISPR's efficiency intensify ethical debates on changing germline.</jats:p>

<jats:p>Balloon-borne detector moves to space to trap rare, high-energy particles that carry clues to their origin.</jats:p>

<jats:p> <jats:italic>Bacillus cereus</jats:italic> , a microbe widely seen as benign, is a mass killer of mammals, researchers say. </jats:p>

<jats:p>Hallmark plaques and tangles found in the largest analysis yet of old chimp brains.</jats:p>