Catálogo de publicaciones - revistas

<jats:title>Sequencing each cell of the nematode</jats:title> <jats:p> Single-cell sequencing is challenging owing to the limited biological material available in an individual cell and the high cost of sequencing across multiple cells. Cao <jats:italic>et al.</jats:italic> developed a two-step combinatorial barcoding method to profile both single-cell and single-nucleus transcriptomes without requiring physical isolation of each cell. The authors profiled almost 50,000 single cells from an individual <jats:italic>Caenorhabditis elegans</jats:italic> larval stage and were able to identify and recover information from different, even rare, cell types. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="661" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aam8940">661</jats:related-article> </jats:p>

<jats:title>When you don't want things to stick</jats:title> <jats:p> During marine fouling, surfaces are encrusted with scale or biological organisms, which can be expensive to remove. Amini <jats:italic>et al.</jats:italic> used polymers infused with organic lubricants to prevent mussels from adhering to a submerged surface. The infused polymer presents a relatively soft surface to the mussel. This means that when the mussel probes the surface with its feet, it is less likely to release adhesive threads, which reduces its adhesion. The antifouling properties of the treatment were observed in both a laboratory setting and field testing. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="668" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aai8977">668</jats:related-article> </jats:p>

<jats:title>Conjugated covalent networks</jats:title> <jats:p> Although graphene and related materials are two-dimensional (2D) fully conjugated networks, similar covalent organic frameworks (COFs) could offer tailored electronic and magnetic properties. Jin <jats:italic>et al.</jats:italic> synthesized a fully π-conjugated COF through condensation reactions of tetrakis(4-formylphenyl)pyrene and 1,4-phenylenediacetonitrile. The reactions were reversible, which provides the self-healing needed to form a crystalline material of stacked, π-bonded 2D sheets. Chemical oxidation of this semiconductor with iodine greatly enhanced its conductivity, and the radicals formed on the pyrene centers imparted a high spin density and paramagnetism. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="673" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan0202">673</jats:related-article> </jats:p>

<jats:title>A spin-valve solar cell</jats:title> <jats:p> Electronic spin currents can be measured with a spin valve—a device that injects charge carriers from one ferromagnetic electrode to another through a semiconductor layer. Some organic semiconductors can have long spin-carrier lifetimes and can also generate charge carriers through the photovoltaic effect. Sun <jats:italic>et al.</jats:italic> fabricated a spin valve based on C <jats:sub>60</jats:sub> and showed that the spin current could be modulated by the photocurrent. At certain light intensities, the sign of the photocurrent could be changed using an applied magnetic field, an effect that could potentially be harnessed for sensing applications. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="677" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan5348">677</jats:related-article> </jats:p>

<jats:title>Unusual star may be supernova debris</jats:title> <jats:p> Type Ia supernovae occur when a white dwarf star is completely destroyed in a thermonuclear explosion. Recently, another class of supernova has been found, dubbed type Iax; these look like type Ia but are much fainter and may be the result of only partial destruction of a white dwarf. In support of this notion, Vennes <jats:italic>et al.</jats:italic> found a white dwarf star in our Galaxy that is low-mass, is moving quickly, and has an unusual composition. These properties suggest that it could be the predicted leftover remains from a type Iax supernova. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="680" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aam8378">680</jats:related-article> </jats:p>

<jats:title>Beating bands in substellar atmospheres</jats:title> <jats:p> Brown dwarfs are objects with masses that are between those of large planets and small stars. They share many features with gas giant planets, particularly conditions in their atmospheres. Apai <jats:italic>et al.</jats:italic> analyzed how the infrared brightness of three brown dwarfs changes over time. Several perplexing features can be explained if bands of clouds rotating within their atmospheres generate beat patterns. Such bands are seen in optical images of Jupiter but best match infrared images of Neptune. The results shed light on the atmospheric physics of brown dwarfs and gas giant planets around the Sun and other stars. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="683" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aam9848">683</jats:related-article> </jats:p>

<jats:title>Faulty remembrance of objects past</jats:title> <jats:p> The primate brain analyzes visual input along the ventral processing stream to extract the identity of an object. The final stage of this stream, the perirhinal cortex, plays a crucial role in object recognition. Tamura <jats:italic>et al.</jats:italic> systematically biased the judgments of monkeys in an old-new object recognition task by using either optogenetic or electrical stimulation. The monkeys judged an encountered object as familiar when the stimulation site was in a hotspot where memory neurons were clustered. However, at the hotspot's fringe region, where neurons lost selective responses to the learned objects, electrical microstimulation led the monkeys to mistakenly judge an object as never seen before. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="687" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan4800">687</jats:related-article> </jats:p>

<jats:title>Sharing data, protecting privacy</jats:title> <jats:p> Although data-sharing is crucial for making the best use of genetic data in diagnosing disease, many individuals who might donate data are concerned about privacy. Jagadeesh <jats:italic>et al.</jats:italic> describe a solution that combines a protocol from modern cryptography with frequency-based clinical genetics used to diagnose causal disease mutations in patients with monogenic disorders. This framework correctly identified the causal gene in cases involving actual patients, while protecting more than 99% of individual participants' most private variants. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="692" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aam9710">692</jats:related-article> </jats:p>

<jats:title>The circuits of itching and scratching</jats:title> <jats:p> Itch is a major clinical problem with poor treatment options. In the past few years, much progress has been made in identifying itch-selective molecules and neurons. However, we know very little about the brain circuits underlying itch processing. Mu <jats:italic>et al.</jats:italic> found that a subpopulation of itch-processing neurons in the spinal cord directly excite other neurons that project to a brain stem structure called the parabrachial nucleus. Inhibition of this spino-parabrachial pathway reduced itching and scratching in mice. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="695" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aaf4918">695</jats:related-article> </jats:p>

<jats:title>Methanogenic archaea metabolism</jats:title> <jats:p> Most of the methane on Earth is produced by the metabolism of methanogenic archaea. The final step involves a reaction between methyl-coenzyme M and coenzyme B to give CoM-S-S-CoB and methane. Wagner <jats:italic>et al.</jats:italic> report a high-resolution structure of the methanogenic heterodisulfide reductase (HdtABC)-[NiFe]-hydrogenase, the enzyme that reduces the disulfide and couples this to the reduction of ferredoxin in an energy-conserving process known as flavin-based electron bifurcation (FBEB) (see the Perspective by Dobbek). The reduced ferredoxin, in turn, drives the first step of methanogenesis. The structure shows how two noncubane [4Fe-4S] clusters perform disulfide cleavage and gives insight into the mechanism of FBEB. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="699" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan0425">699</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6352" page="642" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao2439">642</jats:related-article> </jats:p>