Catálogo de publicaciones - revistas

<jats:p>A cell type in the median preoptic nucleus integrates water intake over time and controls thirst behavior in mice.</jats:p>

<jats:p>In model systems, bacteria present in human pancreatic tumors confer resistance to the anticancer drug gemcitabine.</jats:p>

<jats:p>The population structure in Papua New Guinea reflects a Neolithic transition with high present-day genetic differentiation.</jats:p>

<jats:p> Commercially produced antibodies have become workhorses of basic research, but opaque supply chains, a lack of clear quality standards, and scientists' complacency have turned antibody-based experiments into potential disaster zones. Several strategies can help researchers navigate past these pitfalls. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/custom-publishing/technology-features/agreeable-antibodies-antibody-validation-challenges-and">Read the Feature (Full-Text HTML)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/custom-publishing/documents/15SeptProteomics.pdf">Read the Feature (PDF)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/custom-publishing/douments/15SeptNewProducts.pdf">Read New Products (PDF)</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>

<jats:p> <jats:fig orientation="portrait" position="anchor"> <jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" orientation="portrait" position="float" xlink:href="357_1168c_f1.gif" /> </jats:fig> Fans of the sci-fi series <jats:italic>Star Trek</jats:italic> are familiar with the show's fictional "tricorders," handheld devices used for sensor scanning and data analysis and recording. Yet these futuristic instruments are now, in a sense, entering the real world due to the advent of biosensors, devices that transform the detection of biological elements—antibodies, nucleic acids, cell receptors, enzymes, among others—into signals (e.g., optical, electrochemical) that can be more easily measured and quantified. The technology behind this modern-day measuring equipment is surface plasmon resonance (SPR), a process through which electrons on a metal surface are excited by a polarized light source, creating charge-density waves called plasmons. These plasmons then bend the light at a specific angle (known as the resonance angle) that is picked up through a detector. As molecules bind and dissociate from the metal surface, the resonance angle changes, giving an interaction profile (including binding kinetics, specificity, concentration, and affinity) that is recorded in real time. The possibilities for this technology include proteomics, immunogenicity, and drug discovery, but really are limitless. However, the best use for SPR is precision medicine. This tool could help to more quickly identify molecules or compounds that could aid in treatment of diseases. Conversely, it could also help pinpoint which patients would respond best to a particular drug or vaccine. Included in this booklet are articles from <jats:italic>Science</jats:italic> , <jats:italic>Science Translational Medicine</jats:italic> , and <jats:italic>Science Signaling</jats:italic> that detail the prospects for SPR technology. </jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>

<jats:p>Tumor metastasis is a multistep process that includes stimulation of angiogenesis, intravasation of tumor cells into blood or lymphatic vessels, and subsequent engraftment and extravasation to peripheral tissues where secondary tumors are seeded. It is known that metastatic progression is driven by mutational and epigenetic changes in tumor cells, but more recent efforts have focused on the evolving interplay between the tumor cell and the tumor microenvironment (TME) during invasion and transition from micrometastasis to macrometastasis. Whether the tumor cell or the subverted vascular niche/premetastatic niche is the driver of TME evolution remains the subject of debate. This webinar examines the role of tumor-secreted factors, including exosomes and tumor vascular niche—derived protumorigenic factors in tumor—environment interactions, and their implications for development of therapeutic interventions to arrest metastasis.</jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> <jats:fig orientation="portrait" position="anchor"> <jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" orientation="portrait" position="float" xlink:href="357_1168c_f1.gif" /> </jats:fig> Fans of the sci-fi series <jats:italic>Star Trek</jats:italic> are familiar with the show's fictional "tricorders," handheld devices used for sensor scanning and data analysis and recording. Yet these futuristic instruments are now, in a sense, entering the real world due to the advent of biosensors, devices that transform the detection of biological elements—antibodies, nucleic acids, cell receptors, enzymes, among others—into signals (e.g., optical, electrochemical) that can be more easily measured and quantified. The technology behind this modern-day measuring equipment is surface plasmon resonance (SPR), a process through which electrons on a metal surface are excited by a polarized light source, creating charge-density waves called plasmons. These plasmons then bend the light at a specific angle (known as the resonance angle) that is picked up through a detector. As molecules bind and dissociate from the metal surface, the resonance angle changes, giving an interaction profile (including binding kinetics, specificity, concentration, and affinity) that is recorded in real time. The possibilities for this technology include proteomics, immunogenicity, and drug discovery, but really are limitless. However, the best use for SPR is precision medicine. This tool could help to more quickly identify molecules or compounds that could aid in treatment of diseases. Conversely, it could also help pinpoint which patients would respond best to a particular drug or vaccine. Included in this booklet are articles from <jats:italic>Science</jats:italic> , <jats:italic>Science Translational Medicine</jats:italic> , and <jats:italic>Science Signaling</jats:italic> that detail the prospects for SPR technology. </jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>