Catálogo de publicaciones - revistas

<jats:title>Cutting out circular RNAs</jats:title> <jats:p> Circular RNAs are widespread, but their functions have been controversial. Piwecka <jats:italic>et al.</jats:italic> used CRISPR-Cas9 technology to remove the locus encoding the circular RNA Cdr1as from the mouse genome. Single-cell electrophysiological measurements in excitatory neurons revealed an increase in spontaneous vesicle release from the knockout mice and depression in the synaptic response with two consecutive stimuli, indicating that Cdr1as deficiency leads to dysfunction of excitatory synaptic transmission. Small RNA sequencing of several major regions of the brain showed that expression of two microRNAs, miR-7 and miR-671, that bind to Cdr1as decreased and increased, respectively. These results, along with expression analyses, suggest that neuronal Cdr1as stabilizes or transports miR-7, which in turn represses genes that are early responders to different stimuli. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="eaam8526" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aam8526">eaam8526</jats:related-article> </jats:p>

<jats:title>Phase separation and cellular organization</jats:title> <jats:p>Cells are compartmentalized to allow distinct processes to occur in membrane-delimited organelles. But similar spatial restriction of cellular components in membrane-less intracellular assemblies or condensates also appears to occur—much like oil droplets in water. These compartments contribute to multiple biological processes and regulatory mechanisms. Shin and Brangwynne review the protein-protein and protein-RNA interactions that result in formation of these structures. They explain known and potential functions of such structures in a range of examples, from signaling and local control of biochemical reactants to spatial segregation. In disease, such aggregation may go awry and contribute to neurodegenerative syndromes associated with inappropriate protein aggregation.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="eaaf4382" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aaf4382">eaaf4382</jats:related-article> </jats:p>

<jats:p>Coral reefs around the world have suffered from 3 years of coral bleaching, following three decades of record high temperatures. It is now clear that coral reefs cannot survive, unchanged, under climate change. Their final state will depend not only on societal conviction to restore coral health but also on the ability to sustain investments and action that support this commitment.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>