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<jats:title>Location, location, location</jats:title> <jats:p> The distribution of RNA in cells is important for efficient translation into proteins. Asymmetric RNA localization is known in several cell types but is poorly understood in gut epithelial cells. Moor <jats:italic>et al.</jats:italic> found that transcripts in intestinal enterocytes tend to distribute to the cells' apical or basal cell sides (see the Perspective by Gáspár and Ephrussi). mRNA localization does not generally overlap protein localization; instead, ribosomes are apically biased, which allows more efficient translation. On refeeding of fasted mice, gut cell mRNAs encoding ribosomal proteins exhibit a basal-to-apical shift in localization and a boost in translation. Thus, dynamic polarization of mRNA and polarized translation modulate translational efficiency in the intestinal epithelium. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="1299" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan2399">1299</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="1235" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao5796">1235</jats:related-article> </jats:p>

<jats:title>Taking the PERVs out of pigs</jats:title> <jats:p> With the severe shortage of organs needed for transplants, xenotransplantation (transplantation of nonhuman organs to humans) offers an alternative source. Some pig organs have similar size and function to those of humans. The challenge is that the pig genome harbors porcine endogenous retroviruses (PERVs) that can potentially pass to humans with possibly damaging consequences. Niu <jats:italic>et al.</jats:italic> generated pigs in which all copies of PERVs were inactivated by CRISPR-Cas9 genome engineering (see the Perspective by Denner). Not only does this work provide insights into PERV activity, but it also opens the door to a safer source of organs and tissues for pig-to-human xenotransplantation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="1303" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aan4187">1303</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6357" page="1238" related-article-type="in-this-issue" vol="357" xlink:href="10.1126/science.aao6334">1238</jats:related-article> </jats:p>

<jats:p> This issue of <jats:italic>Science</jats:italic> includes the program of the 2018 Gordon Research Conferences. </jats:p> <jats:p> A <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/cgi/reprint/353/6306/1438.pdf">PDF</jats:ext-link> of the program as it appears in this issue is available here; for more information on the meeting (including registration forms and information on accommodations), please visit <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="www.grc.org">www.grc.org</jats:ext-link> . </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>