Catálogo de publicaciones - revistas

<jats:title>An atlas for drug interactions</jats:title> <jats:p> Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. There are hundreds of kinases within the human body, so knowing the kinase “target” of each drug is essential for developing successful treatment strategies. Sometimes clinical trials can fail because drugs bind more than one target. Yet sometimes off-target effects can be beneficial, and drugs can be repurposed for treatment of additional diseases. Klaeger <jats:italic>et al.</jats:italic> performed a comprehensive analysis of 243 kinase inhibitors that are either approved for use or in clinical trials. They provide an open-access resource of target summaries that could help researchers develop better drugs, understand how existing drugs work, and design more effective clinical trials. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6367" page="eaan4368" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aan4368">eaan4368</jats:related-article> </jats:p>

<jats:p> In their comment, Bui <jats:italic>et al</jats:italic> . argue that the approach we described in our report is vastly inferior in efficiency to alternative off-the-shelf technologies. Their conclusion is invalid, as they compare efficiencies in completely different operating conditions. Here, using heat transfer and thermodynamics principles, we show how Bui <jats:italic>et al</jats:italic> .’s conclusions about the efficiencies of off-the-shelf technologies are fundamentally flawed and inaccurate for the operating conditions described in our study. </jats:p>

<jats:title>Looking sharp with metalenses</jats:title> <jats:p>High-end imaging lenses have tended to be based on bulk optical components. Advances in fabrication techniques have enabled the development of ultrathin, lightweight, and planar lenses (metalenses) that have unprecedented functionalities. These metalenses have the potential to replace or complement their conventional bulk counterparts. Khorasaninejad and Capasso review the evolution of metalenses, summarizing achievements and applications and identifying future challenges and opportunities. Metalenses can have numerous applications, ranging from cellphone camera modules, to wearable displays for augmented and virtual reality and machine vision, to bio-imaging and endoscopy.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6367" page="eaam8100" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aam8100">eaam8100</jats:related-article> </jats:p>

<jats:p> Kim <jats:italic>et al</jats:italic> . (Reports, 28 April 2017, p. 430) presented results for the solar-driven harvesting of water from air via metal-organic frameworks as a prodigious potential advance toward remedying global water shortages. Basic thermodynamics and a survey of multiple off-the-shelf technologies show that their approach is vastly inferior in efficiency (and thereby in feasibility) to available alternatives. </jats:p>

<jats:title>A bona fide portrayal of tumor growth</jats:title> <jats:p> Bone has a well-established role in advanced cancer. It provides a supportive microenvironment for the growth of metastatic cells that escape the primary tumor, which ultimately leads to loss of bone mass. Engblom <jats:italic>et al.</jats:italic> show that bone may also contribute to early-stage tumorigenesis through a mechanism that leads to an increase in bone mass (see the Perspective by Zhang and Lyden). In mouse models of lung adenocarcinoma, primary tumor cells remotely activated bone-resident cells called osteoblasts, which have a bone-building function. The activated osteoblasts in turn triggered production of a certain type of neutrophil that infiltrates the primary tumor and promotes its growth. Patients with early-stage lung cancer were also found to have an increase in bone density, consistent with the findings in mice. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6367" page="eaal5081" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aal5081">eaal5081</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6367" page="1127" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aar2640">1127</jats:related-article> </jats:p>

<jats:p>Since 1990, nearly one million people have died from the impacts of earthquakes. Reducing those impacts requires building a local seismic culture in which residents are aware of earthquake risks and value efforts to mitigate harm. Such efforts include earthquake early warning (EEW) systems that provide seconds to minutes notice of pending shaking. Recent events in Mexico provide an opportunity to assess performance and perception of an EEW system and highlight areas for further improvement. We have learned that EEW systems, even imperfect ones, can help people prepare for earthquakes and build local seismic culture, both beneficial in reducing earthquake-related losses.</jats:p>