Catálogo de publicaciones - revistas

<jats:title>One cause of accidental deaths</jats:title> <jats:p>The number of accidental deaths involving a firearm might be expected to correlate with the number of firearms, but claims that a causal relationship exists have not been persuasive (see the Policy Forum by Cook and Donohue). The 2012 mass shooting at an elementary school in the eastern United States resulted in the deaths of 20 children. Levine and McKnight used the random timing of this event and the subsequent increase in gun purchases (as recorded by an increased number of background checks) to show that the increased exposure to guns resulted in ∼60 accidental deaths.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6368" page="1324" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aan8179">1324</jats:related-article> see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6368" page="1259" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aar3067">1259</jats:related-article> </jats:p>

<jats:title>The flight of the narwhal</jats:title> <jats:p> Animals tend to respond to threats with the well-known behaviors of fight, flee, or freeze, each of which requires a different suite of physiological responses. Marine mammals face particular challenges because they may flee into an environment where oxygen is not available and pressure must be accommodated. Williams <jats:italic>et al.</jats:italic> placed a submersible electrocardiograph, depth, and acceleration recorder on narwhals after they were freed from entanglement. The animals displayed contrary cardiovascular responses simultaneously, which placed extreme stress on the cardiovascular system and the tissues that it protects. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6368" page="1328" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aao2740">1328</jats:related-article> </jats:p>

<jats:title>Gaining a foothold on kidney disease?</jats:title> <jats:p> The leading cause of kidney disease worldwide is known as focal segmental glomerulosclerosis (FSGS). FSGS is associated with loss of podocytes, an unusual cell type critical for the kidney's blood filtration function. Podocytes form interdigitating foot processes that wrap around capillaries and prevent leakage of plasma proteins into urine (proteinuria). Zhou <jats:italic>et al.</jats:italic> suppressed proteinuria by preventing podocyte loss in two different rat models of kidney disease, using a compound that selectively inhibits the TRPC5 ion channel (see the Perspective by Chung and Shaw). In short-term studies, this compound had no detectable side effects. Thus, TRPC5 inhibitors may merit exploration as a therapy for progressive kidney disease. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6368" page="1332" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aal4178">1332</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6368" page="1256" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aar3572">1256</jats:related-article> </jats:p>

<jats:title>A source of methane in the upper ocean</jats:title> <jats:p> Methane concentrations are high in oxygenated surface waters. Methylphosphonate (MPn) is a suggested source, but an enzyme that synthesizes Mpn (MPnS) has so far only been identified in one ocean microbe, albeit an abundant one: the archaeon <jats:italic>Nitrosopumilus maritimus</jats:italic> . Born <jats:italic>et al.</jats:italic> describe the crystal structure of MPnS and of a related enzyme that acts on the same substrate but makes a different product. By comparing the structures, they determined sequence markers that allowed them to identify MPnS in other ocean microbes, including the abundant microbe <jats:italic>Pelagibacter ubique</jats:italic> . These findings support the proposal that MPn is a source of both methane and phosphorus in the upper aerobic ocean. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6368" page="1336" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aao3435">1336</jats:related-article> </jats:p>

<jats:p> Biomarkers for neurological diseases used to be few and far between, but better technology is making it easier for researchers to track brain health by measuring molecules. This means less invasive testing, earlier diagnosis, faster drug development, and—hopefully—more effective treatments. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/features/2017/12/biomarkers-brain-putting-biomarkers-together-better-understanding-nervous-system">Read the Feature (Full-Text HTML)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/8DecProteomicsFeature.pdf">Read the Feature (PDF)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/documents/8DecNewProducts.pdf">Read New Products (PDF)</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>

<jats:p>The human immune system is a constant sentinel, seeking out unwelcome invaders in the body (viruses, bacteria, and the like) as well as nonself elements, including cancer and precancer cells. Tumor cells may use molecular mechanisms to evade discovery or to locally tamp down the immune system’s normal response. To counteract this end-run, researchers need a deep understanding of the complex relationships between different immune cells, and between these cells and their targets. This supplement introduces the reader to groundbreaking research in immuno-oncology, and offers a look at the latest cell analysis tools that are unlocking the secrets of immune cell relationships, potentially enabling future breakthroughs in immune-based therapies.</jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p>The human immune system is a constant sentinel, seeking out unwelcome invaders in the body (viruses, bacteria, and the like) as well as nonself elements, including cancer and precancer cells. Tumor cells may use molecular mechanisms to evade discovery or to locally tamp down the immune system’s normal response. To counteract this end-run, researchers need a deep understanding of the complex relationships between different immune cells, and between these cells and their targets. This supplement introduces the reader to groundbreaking research in immuno-oncology, and offers a look at the latest cell analysis tools that are unlocking the secrets of immune cell relationships, potentially enabling future breakthroughs in immune-based therapies.</jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>

<jats:p> <jats:fig orientation="portrait" position="anchor"> <jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" orientation="portrait" position="float" xlink:href="358_1344b_f1.gif" /> </jats:fig> The basic design and concept of the electron microscope has not changed much since its development in the 1930's, although incremental improvements in power and resolution have been achieved over the decades. More recently, the application of scanning electron microscopy in the biological sciences has enjoyed something of a renaissance, in part because of recent advances in EM technology. This booklet will introduce the reader to a sample of these new technologies and describe how they are being applied in the life sciences. </jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>

<jats:p> <jats:fig orientation="portrait" position="anchor"> <jats:graphic xmlns:xlink="http://www.w3.org/1999/xlink" orientation="portrait" position="float" xlink:href="358_1344b_f1.gif" /> </jats:fig> The basic design and concept of the electron microscope has not changed much since its development in the 1930's, although incremental improvements in power and resolution have been achieved over the decades. More recently, the application of scanning electron microscopy in the biological sciences has enjoyed something of a renaissance, in part because of recent advances in EM technology. This booklet will introduce the reader to a sample of these new technologies and describe how they are being applied in the life sciences. </jats:p> <jats:p> This special supplement brought to you by the <jats:bold>Science</jats:bold> /AAAS Custom Publishing Office. </jats:p>