Catálogo de publicaciones - revistas

<jats:title>Tubulin carboxypeptidase identity revealed</jats:title> <jats:p> Enzymes of the α-tubulin detyrosination/tyrosination cycle create landmarks on microtubules that are essential for their multiple cellular functions and are altered in disease. Tubulin carboxypeptidases (TCPs) responsible for detyrosination have remained elusive for 40 years (see the Perspective by Akhmanova and Maiato). Aillaud <jats:italic>et al.</jats:italic> identified vasohibins as enzymes that perform the TCP function and found that their small interacting partner SBVP was essential for their activity. Vasohibin/SVBP complexes were involved in neuron polarization and brain cortex development. The authors also developed an inhibitor targeting this family of enzymes. Using a completely different strategy, Nieuwenhuis <jats:italic>et al.</jats:italic> also showed that vasohibins can remove the C-terminal tyrosine of α-tubulin. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6369" page="1448" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aao4165">1448</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6369" page="1453" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aao5676">1453</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6369" page="1381" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aar3895">1381</jats:related-article> </jats:p>

<jats:title>A CRISPR device to record time</jats:title> <jats:p> The CRISPR adaptation system has been used to record the sequence and ordering of exogenous oligonucleotides that are electroporated into cell populations. Sheth <jats:italic>et al.</jats:italic> engineered a system bypassing the use of exogenous DNA to directly record temporal signals. An input biological signal is transformed into the ratio of the frequency of incorporating trigger DNA to that of incorporating reference DNA into the genomes of a bacterial population. A multiplexing strategy enables simultaneous recording of three environmental signals with high temporal resolution. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6369" page="1457" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aao0958">1457</jats:related-article> </jats:p>

<jats:title>Macrocycles by design</jats:title> <jats:p> Macrocyclic peptides have diverse properties, including antibiotic and anticancer activities. This makes them good therapeutic leads, but screening libraries only cover a fraction of the sequence space available to peptides comprising D and L amino acids. Hosseinzadeh <jats:italic>et al.</jats:italic> achieved near-complete coverage in sampling the sequence space for 7- to 10-residue cyclic peptides and identified more than 200 designs predicted to fold into stable structures. Of 12 structures determined, nine were close to the computational models. They also sampled and designed 11- to 14-residue macrocycles, but without complete coverage. The designed macrocycles provide a path forward for engineering new therapeutics. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6369" page="1461" related-article-type="in-this-issue" vol="358" xlink:href="10.1126/science.aap7577">1461</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>