Catálogo de publicaciones - revistas

<jats:title>Biophysical responses of proteins to stress</jats:title> <jats:p> Much recent work has focused on liquid-liquid phase separation as a cellular response to changing physicochemical conditions. Because phase separation responds critically to small changes in conditions such as pH, temperature, or salt, it is in principle an ideal way for a cell to measure and respond to changes in the environment. Small pH changes could, for instance, induce phase separation of compartments that store, protect, or inactivate proteins. Franzmann <jats:italic>et al.</jats:italic> used the yeast translation termination factor Sup35 as a model for a phase separation–induced stress response. Lowering the pH induced liquid-liquid phase separation of Sup35. The resulting liquid compartments subsequently hardened into gels, which sequestered the termination factor. Raising the pH triggered dissolution of the gels, concomitant with translation restart. Protecting Sup35 in gels could provide a fitness advantage to recovering yeast cells that must restart the translation machinery after stress. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6371" page="eaao5654" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aao5654">eaao5654</jats:related-article> </jats:p>

<jats:title>Beneath the waves, oxygen disappears</jats:title> <jats:p> As plastic waste pollutes the oceans and fish stocks decline, unseen below the surface another problem grows: deoxygenation. Breitburg <jats:italic>et al.</jats:italic> review the evidence for the downward trajectory of oxygen levels in increasing areas of the open ocean and coastal waters. Rising nutrient loads coupled with climate change—each resulting from human activities—are changing ocean biogeochemistry and increasing oxygen consumption. This results in destabilization of sediments and fundamental shifts in the availability of key nutrients. In the short term, some compensatory effects may result in improvements in local fisheries, such as in cases where stocks are squeezed between the surface and elevated oxygen minimum zones. In the longer term, these conditions are unsustainable and may result in ecosystem collapses, which ultimately will cause societal and economic harm. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6371" page="eaam7240" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aam7240">eaam7240</jats:related-article> </jats:p>

<jats:p>Ideas supported by well-defined and clearly described methods and evidence are one of the cornerstones of science. After several publications indicated that a substantial number of scientific reports may not be readily reproducible, the scientific community and public began engaging in discussions about mechanisms to measure and enhance the reproducibility of scientific projects. In this context, several innovative steps have been taken in recent years. The results of these efforts confirm that improving reproducibility will require persistent and adaptive responses, and as we gain experience, implementation of the best possible practices.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Over a decade, researchers aim to follow 10,000 children through the challenges of adolescence.</jats:p>

<jats:p>DNA from Alaskan infant suggests a long arctic sojourn.</jats:p>