Catálogo de publicaciones - revistas

<jats:title>Phagocytes patrol intestinal fungi</jats:title> <jats:p> Maintaining a healthy balance of gut bacteria can promote good health. Leonardi <jats:italic>et al.</jats:italic> show that fungi can also interact with gut immune cells to maintain intestinal well-being. CX3CR1 <jats:sup>+</jats:sup> mononuclear phagocytes (MNPs) patrol the intestine and promote antifungal immunity. Genetic deletion of CX3CR1 in MNPs caused colitis-like symptoms in mice. CX3CR1 polymorphisms were detected in Crohn's disease patients that were unable to produce antibodies against multiple fungal species. Thus, commensal fungi may be as important as bacteria in maintaining gut health, and antifungal therapy could hold promise for treating intestinal inflammation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6372" page="232" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aao1503">232</jats:related-article> </jats:p>

<jats:title>Architecture of the TRPM subfamily</jats:title> <jats:p> Transient receptor potential melastatin (TRPM) ion channels constitute the largest TRP subfamily and are involved in many physiological processes. TRPM8 is the primary cold and menthol sensor, and TRPM4 is associated with cardiovascular disorders. Yin <jats:italic>et al.</jats:italic> and Autzen <jats:italic>et al.</jats:italic> shed light on the general architecture of the TRPM subfamily by solving the structures of TRPM8 and TRPM4, respectively (see the Perspective by Bae <jats:italic>et al.</jats:italic> ). The three-layered architecture of the TRPM8 channel provides the framework for understanding the mechanisms of cold and menthol sensing. The two distinct closed states of TRPM4, with and without calcium, reveal a calcium-binding site and calcium-binding-induced conformational changes. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6372" page="237" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aan4325">237</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6372" page="228" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar4510">228</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6372" page="160" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar6205">160</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>