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Science

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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

Editors' Choice

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286-287

How hunting affects brown bear populations

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286.1-287

Going dry in the Pacific Northwest

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286.2-286

Time-out for mRNAs in the nucleus

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286.3-286

Serious damage by soluble tau

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286.4-287

Lighting up riboswitching

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286.5-287

The value of scaffolds

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286.6-287

Social skills to pay the bills

Caroline Ash; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 286.7-287

Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design

Yushen DuORCID; Li Xin; Yuan ShiORCID; Tian-Hao ZhangORCID; Nicholas C. WuORCID; Lei Dai; Danyang Gong; Gurpreet BrarORCID; Sara ShuORCID; Jiadi LuoORCID; William Reiley; Yen-Wen Tseng; Hongyan Bai; Ting-Ting WuORCID; Jieru WangORCID; Yuelong Shu; Ren SunORCID

<jats:title>Avoiding interferon avoidance</jats:title> <jats:p> Interferon (IFN) expression is a mammal's first response to viral infection. Many viruses have thus evolved mechanisms to evade IFN. Du <jats:italic>et al.</jats:italic> developed a method to systematically ablate IFN evasion genes from live, attenuated influenza virus (see the Perspective by Teijaro and Burton). A combination of mutants was assembled to construct a virus that triggered transient IFN responses in mice but that was unable to replicate effectively. The transient IFN responses led to robust antibody and memory responses that protected against subsequent challenge with different influenza viruses. This approach could be adapted to improve other RNA virus vaccines. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6373" page="290" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aan8806">290</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6373" page="277" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar5421">277</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 290-296

A self-assembled nanoscale robotic arm controlled by electric fields

Enzo KoppergerORCID; Jonathan ListORCID; Sushi MadhiraORCID; Florian RothfischerORCID; Don C. LambORCID; Friedrich C. SimmelORCID

<jats:title>Electrically driving a DNA arm</jats:title> <jats:p> Most nanoelectromechanical systems are formed by etching inorganic materials such as silicon. Kopperger <jats:italic>et al.</jats:italic> improved the precision of such machines by synthesizing a 25-nm-long arm defined by a DNA six-helix bundle connected to a 55 nm-by-55 nm DNA origami plate via flexible single-stranded scaffold crossovers (see the Perspective by Hogberg). When placed in a cross-shaped electrophoretic chamber, the arms could be driven at angular frequencies of up to 25 Hz and positioned to within 2.5 nm. The arm could be used to transport fluorophores and inorganic nanoparticles. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6373" page="296" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aao4284">296</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6373" page="279" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar6580">279</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 296-301