Catálogo de publicaciones - revistas

<jats:title>Dwarf galaxies move in unexpected ways</jats:title> <jats:p> Massive galaxies like our Milky Way are orbited by satellite dwarf galaxies. Standard cosmological simulations of galaxy formation predict that these satellites should move randomly around their host. Müller <jats:italic>et al.</jats:italic> examined the satellites of the nearby elliptical galaxy Centaurus A (see the Perspective by Boylan-Kolchin). They found that the satellites are distributed in a planar arrangement, and the members of the plane are orbiting in a coherent direction. This is inconsistent with more than 99% of comparable galaxies in simulations. Centaurus A, the Milky Way, and Andromeda all have highly statistically unlikely satellite systems. This observational evidence suggests that something is wrong with standard cosmological simulations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6375" page="534" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aao1858">534</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6375" page="520" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar7375">520</jats:related-article> </jats:p>

<jats:title>Structure of the human spliceosome</jats:title> <jats:p> Catalyzed by the spliceosome, precursor mRNA splicing proceeds in two steps: branching and exon ligation. Transition from the C (catalytic post-branching spliceosome) to the C* (catalytic pre-exon ligation spliceosome) complex is driven by the adenosine triphosphatase/helicase Prp16. Zhan <jats:italic>et al.</jats:italic> report the cryo-electron microscopy structure of the human C complex, showing that two step I splicing factors stabilize the active site and link it to Prp16. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6375" page="537" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar6401">537</jats:related-article> </jats:p>