Catálogo de publicaciones - revistas

<jats:title>Toward programmed therapeutics</jats:title> <jats:p> Advances in synthetic biology are enabling the development of new gene and cell therapies. Kitada <jats:italic>et al.</jats:italic> review recent successes in areas such as cancer immunotherapy and stem cell therapy, point out the limitations of current approaches, and describe prospects for using synthetic biology to overcome these challenges. Broader adoption of these therapies requires precise, context-specific control over cellular behavior. Gene circuits can be built to give sophisticated control over cellular behaviors so that therapeutic functions can, for example, be programmed to activate in response to disease biomarkers. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aad1067">eaad1067</jats:related-article> </jats:p>

<jats:p>The ongoing confrontation with North Korea is a reminder that the world must prevent nuclear weapons from ever being used again. North Korea's development of a nuclear arsenal and delivery systems that could threaten the U.S. mainland, South Korea, and Japan has heightened the possibility of a disastrous conflict with hundreds of thousands of casualties. If constructive dialogue does not happen soon, the United States and North Korea may ratchet up tensions and take increasingly provocative actions. The decision by North and South Korea to field a combined team in the Winter Olympics gives hope for broader engagement, but diplomacy by scientists might be one step toward a more lasting rapprochement.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Competition with China accelerates plans for next great leap in supercomputing power.</jats:p>

<jats:p>The nation's first exascale system is expected in 2020.</jats:p>

<jats:p>Gene expression findings from study of hundreds of human brains could lead to diagnostic tests, therapies.</jats:p>

<jats:p>Swelling supplies and a better formulation bolster response to widespread outbreaks.</jats:p>

<jats:p>Animal studies show dangerous side effects from virus increasingly used to deliver DNA to treat diseases.</jats:p>

<jats:p>Philip Morris's $1 billion effort to promote studies of "harm reduction" prompts some researchers to call for a boycott.</jats:p>

<jats:p>Short-lived chemicals may be the culprit.</jats:p>