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<jats:title>Left- or right-handed C–H bond activation</jats:title> <jats:p> Although organic compounds consist mostly of carbon and hydrogen atoms, strategies for chemical synthesis have traditionally targeted the handful of more reactive interspersed oxygens, nitrogens, and halogens. Modifying C–H bonds directly is a more appealing approach, but selectivity remains a challenge. Saint-Denis <jats:italic>et al.</jats:italic> review recent progress in using transition metal catalysis to break just one of two mirror-image C–H bonds and then append a more complex substituent in its place. Ligand design has proven crucial to differentiate these otherwise similar bonds in a variety of molecular settings. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aao4798">eaao4798</jats:related-article> </jats:p>

<jats:p>Labinger argues that stepwise reaction of methane with water to produce methanol and hydrogen will never be commercially feasible because of its substoichiometric basis with respect to the active site and the requirement of a large temperature swing. This comment is not touching any new ground, beyond describing the thermodynamic feasibility, thermal cycling, and the role of water as discussed previously. Most important, it does not have a solid numerical basis.</jats:p>