Catálogo de publicaciones - revistas

<jats:title>Air pollution evolution</jats:title> <jats:p> Transport-derived emissions of volatile organic compounds (VOCs) have decreased owing to stricter controls on air pollution. This means that the relative importance of chemicals in pesticides, coatings, printing inks, adhesives, cleaning agents, and personal care products has increased. McDonald <jats:italic>et al.</jats:italic> show that these volatile chemical products now contribute fully one-half of emitted VOCs in 33 industrialized cities (see the Perspective by Lewis). Thus, the focus of efforts to mitigate ozone formation and toxic chemical burdens need to be adjusted. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="760" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aaq0524">760</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="744" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar4925">744</jats:related-article> </jats:p>

<jats:title>Estimating the predictability of evolution</jats:title> <jats:p> Evolution results from expected effects, such as selection driving alleles toward fixation, and stochastic effects, such as unusual environmental variation and genetic drift. To determine the potential to predict evolutionary change, Nosil <jats:italic>et al.</jats:italic> examined three naturally occurring morphs of stick insects (see the Perspective by Reznick and Travis). They wanted to determine which selective parameters could be used to foresee changes, despite varying environmental conditions. One morph fit a model of negative frequency-dependent selection, likely owing to predation, but changes in other morph frequencies remained unpredictable. Thus, for specific cases, we can forecast short-term changes within populations, but evolution is more difficult to predict when it involves a balance between multiple selective factors and uncertainty in environmental conditions. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="765" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aap9125">765</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="738" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aas9043">738</jats:related-article> </jats:p>

<jats:title>SNF'ing out antitumor immunity</jats:title> <jats:p> Immune checkpoint inhibitors induce durable tumor regressions in some, but not all, cancer patients. Understanding the mechanisms that determine tumor sensitivity to these drugs could potentially expand the number of patients who benefit (see the Perspective by Ghorani and Quezada). Pan <jats:italic>et al.</jats:italic> discovered that tumor cells in which a specific SWI/SNF chromatin remodeling complex had been experimentally inactivated were more sensitive to T cell–mediated killing. The cells were more responsive to interferon-γ, leading to increased secretion of cytokines that promote antitumor immunity. Miao <jats:italic>et al.</jats:italic> examined the genomic features of tumors from patients with metastatic renal cell carcinoma who had been treated with immune checkpoint inhibitors. Tumors harboring inactivating mutations in <jats:italic>PBRM1</jats:italic> , which encodes a subunit of the same SWI/SNF complex, were more likely to respond to the drugs. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="770" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aao1710">770</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="801" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aan5951">801</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="745" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aat0383">745</jats:related-article> </jats:p>

<jats:title>It's a wrap</jats:title> <jats:p> Whether an object has a regular or irregular shape, wrapping it with a thin film can be challenging. Kumar <jats:italic>et al.</jats:italic> released droplets of oil above thin polymer sheets floating on water (see the Perspective by Amstad). With sufficient impact force, the polymer wrapped around the droplet with near perfect seams. The shape of the resulting enclosed drop depended on the shape of the sheet initially placed at the air-liquid interphase. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="775" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aao1290">775</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6377" page="743" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar4027">743</jats:related-article> </jats:p>