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Science

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Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

Mutation dynamics and fitness effects followed in single cells

Lydia RobertORCID; Jean OllionORCID; Jerome Robert; Xiaohu SongORCID; Ivan MaticORCID; Marina ElezORCID

<jats:title>Mutation rates and effects in single cells</jats:title> <jats:p> Understanding the dynamics of mutations and the distribution of fitness effects is critical for most evolutionary models. Robert <jats:italic>et al.</jats:italic> used a single-cell technology to visualize the accumulation of new mutations. The method identifies DNA sequences with mispaired bases and small insertions or deletions caused by DNA replication errors in living <jats:italic>Escherichia coli</jats:italic> cells. Following the fates of cells after mutation allowed for a precise quantification of the effects of new mutations. A smaller fraction of mutations were found to be deleterious than predicted previously from indirect observations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6381" page="1283" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aan0797">1283</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1283-1286

New Products

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1290-1290

Technology Feature | In vitro veritas: Biosensors and micro-arrays come to life

Alan Dove

<jats:p>Advances in biosensors and microfluidic devices are driving a quiet revolution in biomedical research, which could lead to the reduction or elimination of animal use in many experiments.</jats:p>

Palabras clave: Multidisciplinary.

Pp. 1290-1290

Instagram won't solve inequality

Meghan Wright

Palabras clave: Multidisciplinary.

Pp. 1294-1294

Can a new study tell you how to avoid getting sick on a plane—or just the best bathroom to use?

David Shultz

Palabras clave: Multidisciplinary.

Pp. No disponible

U.K. attack shines spotlight on deadly nerve agent developed by Soviet scientists

Richard Stone

Palabras clave: Multidisciplinary.

Pp. No disponible

Some dogs were royalty, others were dinner in ancient Mayan culture

Michael Price

Palabras clave: Multidisciplinary.

Pp. No disponible

Mysterious asteroid from beyond our solar system probably came from a place with two stars

Sid Perkins

Palabras clave: Multidisciplinary.

Pp. No disponible

Scientists have brewed a hoppy-tasting beer—without the hops

Katie Langin

Palabras clave: Multidisciplinary.

Pp. No disponible

American cockroaches thrive in cities, thanks to their incredibly long genomes

Kimberly Hickok

Palabras clave: Multidisciplinary.

Pp. No disponible