Catálogo de publicaciones - revistas

<jats:title>ISRIB mechanism of action</jats:title> <jats:p> In rodents, a druglike small molecule named ISRIB enhances cognition and reverses cognitive deficits after traumatic brain injury. ISRIB activates a protein complex called eIF2B that is required for the synthesis of new proteins. Tsai <jats:italic>et al.</jats:italic> report the visualization of eIF2B bound to ISRIB at near-atomic resolution by cryo–electron microscopy. Biochemical studies revealed that ISRIB is a “molecular staple” that promotes assembly of the fully active form of eIF2B. Zyryanova <jats:italic>et al.</jats:italic> report similar structures together with information on the binding of ISRIB analogs and their effects on protein translation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaq0939">eaaq0939</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6383" page="1533" related-article-type="in-this-issue" vol="359" xlink:href="10.1126/science.aar5129">1533</jats:related-article> </jats:p>

<jats:p>Horner and Pohl argue that high water transport rates reported for carbon nanotube porins (CNTPs) originate from leakage at the nanotube-bilayer interface. Our results and new experimental evidence are consistent with transport through the nanotube pores and rule out a defect-mediated transport mechanism. Mechanistic origins of the high Arrhenius factor that we reported for narrow CNTPs at pH 8 require further investigation.</jats:p>

<jats:p> Tunuguntla <jats:italic>et al</jats:italic> . (Reports, 25 August 2017, p. 792) report that permeation of single-file water occurs faster through carbon nanotubes than through aquaporins. We show that this conclusion violates fundamental thermodynamic laws: Because of its much lower activation energy, aquaporin-mediated water transport must be orders of magnitude faster. Leakage at the nanotube-membrane interface may explain the discrepancy. </jats:p>

<jats:p>We are the whistle-blowers. Our ethical obligations as scientists made it impossible for us to accept a publication of fabricated results, even though it could have cost us our scientific careers. The process was slow and arduous, but worked nevertheless. Would we do it again? Yes. It was something we had to do to retain our trust in science.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Lawmakers largely reject deep cuts proposed by President Donald Trump for 2018.</jats:p>

<jats:p>Studies are based on flawed evidence and could harm patients, scientists say.</jats:p>

<jats:p>Targets included nearly 8000 professors in 22 countries.</jats:p>