Catálogo de publicaciones - revistas

<jats:title>A quick fix for leaky endosomes</jats:title> <jats:p> Cells internalize diverse material through various forms of endocytosis into an extensive endolysosomal network. Protecting the integrity of endolysosomal membranes in both physiological and pathophysiological contexts is critical to cell health. Skowyra <jats:italic>et al.</jats:italic> describe a role for the ESCRT (endosomal sorting complex required for transport) machinery on endolysosomal organelles during membrane repair (see the Perspective by Gutierrez and Carlton). The ESCRTs act as first responders to repair limited membrane damage and thereby restore compartmental integrity and function. This ESCRT activity is distinct from organelle disposal pathways. These findings will be important in understanding cellular responses to invading pathogens and potentially disruptive proinflammatory particulates. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aar5078">eaar5078</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6384" page="33" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat2630">33</jats:related-article> </jats:p>

<jats:p>Next week on 14 April, the March for Science will once again demonstrate the widespread public support for science around the world. Nowhere is this message more needed than in Washington, D.C., where the federal government continues to ignore the value of independent science advice to inform decision-making. Given this lack of expertise at the national level, it is critical to bolster the role of science in policy-making at the state government level. Here, California can lead by example.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>This year's event, set for 14 April, is only one element in a global pro-science movement.</jats:p>

<jats:p>The Ohio State University wins plaudits for unusually rapid transparency.</jats:p>

<jats:p>By identifying effective anesthetics, findings aid compliance with regulations.</jats:p>

<jats:p>A new center named for the Nobel laureate faces funding and mission challenges.</jats:p>

<jats:p>Agency re-reviewed dozens of funding proposals after officials discovered a violation of the rules.</jats:p>

<jats:p>Routinely giving antibiotics to premature babies may do more harm than good.</jats:p>

<jats:p>India's paleontologists are struggling to save fossil sites—and their own discipline.</jats:p>