Catálogo de publicaciones - revistas

<jats:title>Continuing the resolution revolution</jats:title><jats:p>The living cell contains dynamic, spatially complex subassemblies that are sensitive to external perturbations. To minimize such perturbations, cells should be imaged in their native multicellular environments, under as gentle illumination as possible. However, achieving the spatiotemporal resolution needed to follow three-dimensional subcellular processes in detail under these conditions is challenging: Sample-induced aberrations degrade resolution and sensitivity, and high resolution usually requires intense excitation. Liu<jats:italic>et al.</jats:italic>combined noninvasive lattice light-sheet microscopy with aberration-correcting adaptive optics to study a variety of delicate subcellular events in vivo, including organelle remodeling during mitosis and growth cone dynamics during spinal cord development.</jats:p><jats:p><jats:italic>Science</jats:italic>, this issue p.<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaq1392">eaaq1392</jats:related-article></jats:p>

<jats:title>Trigenic interactions in yeast link bioprocesses</jats:title> <jats:p> To dissect the genotype-phenotype landscape of a cell, it is necessary to understand interactions between genes. Building on the digenic protein-protein interaction network, Kuzmin <jats:italic>et al.</jats:italic> created a trigenic landscape of yeast by using a synthetic genetic array (see the Perspective by Walhout). Triple-mutant analyses indicated that the majority of genes with trigenic associations functioned within the same biological processes. These converged on networks identified in the digenic interaction landscape. Although the overall effects were weaker for trigenic than for digenic interactions, trigenic interactions were more likely to bridge biological processes in the cell. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aao1729">eaao1729</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6386" page="269" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat4667">269</jats:related-article> </jats:p>

<jats:p>Forensic evidence plays a critical role in court proceedings and the administration of justice. It is a powerful tool that can help convict the guilty and avoid wrongful conviction of the innocent. Unfortunately, flaws in forensic evidence are increasingly becoming apparent. Assessments of forensic science have too often focused only on the data and the underlying science, as if they exist in isolation, without sufficiently addressing the process by which forensic experts evaluate and interpret the evidence. After all, it is the forensic expert who observes the data and makes interpretations, and therefore forensic evidence is mediated by human and cognitive factors. A U.S. National Research Council examination of forensic science in 2009, followed by a 2016 evaluation by a presidential panel, along with a U.K. inquiry into fingerprinting in 2011 and a 2015 guidance by the U.K. Forensic Science Regulator, have all expressed concerns about biases in forensic expert decision-making. Where does forensic bias come from, and how can we minimize it?</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>By listening for marsquakes, InSight will measure Red Planet's core, mantle, and crust.</jats:p>

<jats:p>Fine-particle sentinels prod governments to curb emissions.</jats:p>

<jats:p>Growing body of data suggests ritual drug use by ancient Mesopotamians, Cypriots, and others.</jats:p>