Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Mariella G. Filbin
; Itay Tirosh; Volker Hovestadt; McKenzie L. Shaw; Leah E. Escalante; Nathan D. Mathewson; Cyril Neftel; Nelli Frank; Kristine Pelton; Christine M. Hebert; Christine Haberler; Keren Yizhak; Johannes Gojo; Kristof Egervari; Christopher Mount; Peter van Galen; Dennis M. Bonal; Quang-De Nguyen; Alexander Beck; Claire Sinai; Thomas Czech; Christian Dorfer; Liliana Goumnerova; Cinzia Lavarino; Angel M. Carcaboso; Jaume Mora; Ravindra Mylvaganam; Christina C. Luo; Andreas Peyrl; Mara Popović; Amedeo Azizi; Tracy T. Batchelor; Matthew P. Frosch; Maria Martinez-Lage; Mark W. Kieran; Pratiti Bandopadhayay; Rameen Beroukhim; Gerhard Fritsch; Gad Getz; Orit Rozenblatt-Rosen; Kai W. Wucherpfennig; David N. Louis; Michelle Monje; Irene Slavc; Keith L. Ligon; Todd R. Golub; Aviv Regev; Bradley E. Bernstein; Mario L. Suvà
<jats:title>The cellular composition of H3K27M gliomas</jats:title> <jats:p> Diffuse midline gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) are an aggressive type of childhood cancer with few options for treatment. Filbin <jats:italic>et al.</jats:italic> used a single-cell sequencing approach to study the oncogenic programs, genetics, and cellular hierarchies of H3K27M-glioma. Tumors were mainly composed of cells resembling oligodendrocyte precursor cells, whereas differentiated malignant cells were a smaller fraction. In comparison with other gliomas, these cancers had distinct oncogenic programs and stem cell–like profiles that contributed to their stable tumor-propagating potential. The analysis also identified a lineage-specific marker that may be useful in developing therapies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6386" page="331" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aao4750">331</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 331-335
MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
Agostinho G. Rocha; Antonietta Franco; Andrzej M. Krezel; Jeanne M. Rumsey; Justin M. Alberti; William C. Knight; Nikolaos Biris; Emmanouil Zacharioudakis; James W. Janetka; Robert H. Baloh; Richard N. Kitsis; Daria Mochly-Rosen; R. Reid Townsend; Evripidis Gavathiotis; Gerald W. Dorn
<jats:title>An innovative approach for a rare disease</jats:title> <jats:p> Charcot-Marie-Tooth disease type 2A (CMT2A) is a rare, inherited neurodegenerative condition. Affected individuals develop severe progressive muscle weakness, motor deficits, and peripheral neuropathy. Although defects in the gene encoding mitofusin 2 (MFN2) are known to cause CMT2A, the disease remains incurable. Rocha <jats:italic>et al.</jats:italic> identified specific MFN2 residues contributing to the disease and developed a class of MFN2-agonist drugs. The small molecules restored mitochondrial fusion and activity in the sciatic nerves of mice; they may also help in other diseases linked to mitochondrial trafficking. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6386" page="336" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aao1785">336</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 336-341
New Products
<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 342-342
Academia's forgotten footnote
Arnav Chhabra
Palabras clave: Multidisciplinary.
Pp. 350-350
Salk puts cancer scientist Inder Verma on leave after harassment allegations, announces investigation
Meredith Wadman
Palabras clave: Multidisciplinary.
Pp. No disponible
Can a genetic weapon combat one of the world’s major crop destroyers?
Roni Dengler
Palabras clave: Multidisciplinary.
Pp. No disponible
Solar cells that work in low light could charge devices indoors
Robert Service
Palabras clave: Multidisciplinary.
Pp. No disponible
Gene linked to breastfeeding may have boosted survival of earliest Americans
Ann Gibbons
Palabras clave: Multidisciplinary.
Pp. No disponible
Whale skulls act like antennas, CT scans reveal
Jeremy Rehm
Palabras clave: Multidisciplinary.
Pp. No disponible
If you listen closely, the drumbeats of Amazonian tribes sound like human speech
Catherine Matacic
Palabras clave: Multidisciplinary.
Pp. No disponible