Catálogo de publicaciones - revistas

<jats:title>Curving bones</jats:title> <jats:p> On larger length scales, bone is known to have a hierarchical structure in which small crystals of calcium phosphates arrange themselves around helices of collagen. These make up larger structures, such as the osteons found in compact bone. However, at smaller lengths, does the hierarchical structure persist? By combining three-dimensional electron tomography with two-dimensional electron microscopy, Reznikov <jats:italic>et al.</jats:italic> observed structural ordering from the nanoscale upward. At the smallest scale, needle-shaped mineral units form platelets that organize into stacks bridging multiple collagen units. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aao2189">eaao2189</jats:related-article> </jats:p>

<jats:title>Saturating malaria mutagenesis</jats:title> <jats:p> Malaria is caused by eukaryotic <jats:italic>Plasmodium</jats:italic> spp. parasites that classically infect red blood cells. These are difficult organisms to investigate genetically because of their AT-rich genomes. Zhang <jats:italic>et al.</jats:italic> have exploited this peculiarity by using <jats:italic>piggyBac</jats:italic> transposon insertion sites to achieve saturation-level mutagenesis for identifying and ranking essential genes and drug targets (see the Perspective by White and Rathod). Genes that are current candidates for drug targets were identified as essential, in contrast to many vaccine target genes. Notably, the proteasome degradation pathway was confirmed as a target for developing therapeutic interventions because of the several essential genes involved and the link to the mechanism of action of the current frontline drug, artemisinin. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aap7847">eaap7847</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6388" page="490" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat5092">490</jats:related-article> </jats:p>

<jats:p>We are at the beginning of the “fourth industrial revolution,” with unprecedented capabilities to acquire, process, and communicate data. As with all revolutions, it holds great promise as well as dangers. Outrage at large-scale privacy breaches demonstrates the perils of taking protection of personal data lightly and reminds us that technological progress challenges policies, values, and approaches to ethics. The European Union (EU) General Data Protection Regulation (GDPR) that takes effect on 25 May offers never-before-seen protections and control by individuals of their personal data, including many provisions for research. Although this should increase public trust and therefore propensity to share data, many implementation details and safeguards have yet to be established. It is clear, however, that interoperability of policies will be essential to promote data sharing across research communities within the EU and globally.</jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>They say new policy aims to weaken air pollution regulations by barring key studies.</jats:p>

<jats:p>Researchers use publicly available data to reproduce previous findings.</jats:p>