Catálogo de publicaciones - revistas

<jats:title>Toxic hijack of a cell signaling pathway</jats:title> <jats:p> The pathogen <jats:italic>Clostridium difficile</jats:italic> colonizes the human colon when the normal microbiota is disrupted, often after antibiotic treatment. It is a leading cause of hospital-acquired diarrhea, especially among elderly patients. Chen <jats:italic>et al.</jats:italic> describe a 2.5-Å-resolution crystal structure that shows how a major virulence factor in <jats:italic>C. difficile</jats:italic> , toxin B (TcdB), binds to the G protein–coupled receptor Frizzled (FZD). This receptor activates the Wnt signaling pathway, which regulates homeostasis of the colonic epithelium. Surprisingly, TcdB uses a lipid cofactor to recognize FZD. This cofactor replaces a lipid normally associated with the Wnt ligand that binds FZD to activate signaling. Inhibiting the Wnt pathway likely plays a role in <jats:italic>C. difficile</jats:italic> pathology. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6389" page="664" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aar1999">664</jats:related-article> </jats:p>

<jats:p> The Institute of Physics (IOP) at the Chinese Academy of Sciences (CAS) is the flagship physics research institute in China. IOP is also designated as the National Research Center for Condensed Matter Physics, one of six centers recently named by the country’s Ministry of Science and Technology. The collection of articles in this supplement represent selected major achievements in condensed matter physics research over IOP’s 90-year history, as well as the innovations in technology and industry that have resulted. IOP’s latest development is also discussed—a group of multiple infrastructures and R&amp;D facilities in Huairou Science City, a planned science center with a 100-km <jats:sup>2</jats:sup> area, located in the northeast suburbs of Beijing. </jats:p> <jats:p> This special supplement brought to you by the <jats:italic>Science</jats:italic> /AAAS Custom Publishing Office. </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>

<jats:p> In the 35 years since its invention, polymerase chain reaction (PCR) has become a standard technique in laboratory biology, but scientists continue to find groundbreaking—and even life-saving—applications for it. <jats:list list-type="bullet"> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/features/2018/05/pcr-thirty-five-years-and-counting">Read the Feature (Full-Text HTML)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/11MayMolecularBiology.pdf">Read the Feature (PDF)</jats:ext-link> </jats:p> </jats:list-item> <jats:list-item> <jats:p> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.sciencemag.org/sites/default/files/documents/11MayNewProducts.pdf">Read New Products (PDF)</jats:ext-link> </jats:p> </jats:list-item> </jats:list> </jats:p>