Catálogo de publicaciones - revistas
Science
Resumen/Descripción – provisto por la editorial
No disponible.
Palabras clave – provistas por la editorial
No disponibles.
Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
RNA buffers the phase separation behavior of prion-like RNA binding proteins
Shovamayee Maharana
; Jie Wang; Dimitrios K. Papadopoulos; Doris Richter; Andrey Pozniakovsky; Ina Poser; Marc Bickle; Sandra Rizk; Jordina Guillén-Boixet; Titus M. Franzmann; Marcus Jahnel; Lara Marrone; Young-Tae Chang; Jared Sterneckert; Pavel Tomancak; Anthony A. Hyman; Simon Alberti
<jats:title>RNA and membraneless organelles</jats:title> <jats:p> Membraneless compartments can form in cells through liquidliquid phase separation (see the Perspective by Polymenidou). But what prevents these cellular condensates from randomly fusing together? Using the RNA-binding protein (RBP) Whi3, Langdon <jats:italic>et al.</jats:italic> demonstrated that the secondary structure of different RNA components determines the distinct biophysical and biological properties of the two types of condensates that Whi3 forms. Several RBPs, such as FUS and TDP43, contain prion-like domains and are linked to neurodegenerative diseases. These RBPs are usually soluble in the nucleus but can form pathological aggregates in the cytoplasm. Maharana <jats:italic>et al.</jats:italic> showed that local RNA concentrations determine distinct phase separation behaviors in different subcellular locations. The higher RNA concentrations in the nucleus act as a buffer to prevent phase separation of RBPs; when mislocalized to the cytoplasm, lower RNA concentrations trigger aggregation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6391" page="922" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aar7432">922</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6391" page="918" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aar7366">918</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6391" page="859" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat8028">859</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 918-921
mRNA structure determines specificity of a polyQ-driven phase separation
Erin M. Langdon; Yupeng Qiu; Amirhossein Ghanbari Niaki; Grace A. McLaughlin; Chase A. Weidmann; Therese M. Gerbich; Jean A. Smith; John M. Crutchley; Christina M. Termini; Kevin M. Weeks; Sua Myong; Amy S. Gladfelter
<jats:title>RNA and membraneless organelles</jats:title> <jats:p> Membraneless compartments can form in cells through liquidliquid phase separation (see the Perspective by Polymenidou). But what prevents these cellular condensates from randomly fusing together? Using the RNA-binding protein (RBP) Whi3, Langdon <jats:italic>et al.</jats:italic> demonstrated that the secondary structure of different RNA components determines the distinct biophysical and biological properties of the two types of condensates that Whi3 forms. Several RBPs, such as FUS and TDP43, contain prion-like domains and are linked to neurodegenerative diseases. These RBPs are usually soluble in the nucleus but can form pathological aggregates in the cytoplasm. Maharana <jats:italic>et al.</jats:italic> showed that local RNA concentrations determine distinct phase separation behaviors in different subcellular locations. The higher RNA concentrations in the nucleus act as a buffer to prevent phase separation of RBPs; when mislocalized to the cytoplasm, lower RNA concentrations trigger aggregation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6391" page="922" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aar7432">922</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6391" page="918" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aar7366">918</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6391" page="859" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat8028">859</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. 922-927
New Products
<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 928-928
What I learned from teaching
Moamen Elmassry
Palabras clave: Multidisciplinary.
Pp. 934-934
The Great Barrier Reef has had five near-death experiences in the past 30,000 years
Katie Langin
Palabras clave: Multidisciplinary.
Pp. No disponible
Stick insects travel long distances—by being eaten by birds
Michael Allen
Palabras clave: Multidisciplinary.
Pp. No disponible
Will U.S. academies expel sexual harassers?
Meredith Wadman
Palabras clave: Multidisciplinary.
Pp. No disponible
United Kingdom unveils ambitious air pollution plan
Matt Warren
Palabras clave: Multidisciplinary.
Pp. No disponible
This ancient fish was bigger than a whale shark—and faster than scientists ever imagined
Colin Barras
Palabras clave: Multidisciplinary.
Pp. No disponible
Discovery of middleweight black holes could explain origin of million-solar-mass monsters
Daniel Clery
Palabras clave: Multidisciplinary.
Pp. No disponible