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Disponibilidad
Institución detectada Período Navegá Descargá Solicitá
No detectada desde mar. 1997 / hasta dic. 2023 Science Journals

Información

Tipo de recurso:

revistas

ISSN impreso

0036-8075

ISSN electrónico

1095-9203

Editor responsable

American Association for the Advancement of Science (AAAS)

País de edición

Estados Unidos

Fecha de publicación

Cobertura temática

Tabla de contenidos

The San Andreas creeps along the decade

Sacha Vignieri; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 1083.1-1083

The long and short of RNA export

Sacha Vignieri; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 1083.2-1084

An algal transformation in Lake Baikal

Sacha Vignieri; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 1083.3-1084

Tissue-specific DNA demethylation after birth

Sacha Vignieri; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 1083.4-1084

Not just a LARK

Sacha Vignieri; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 1083.5-1084

Genomic crowdsourcing with privacy

Sacha Vignieri; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 1083.6-1084

Hurting the most vulnerable

Sacha Vignieri; Jesse Smith (eds.)

Palabras clave: Multidisciplinary.

Pp. 1083.7-1084

A LIMA1 variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption

Ying-Yu ZhangORCID; Zhen-Yan FuORCID; Jian WeiORCID; Wei Qi; Gulinaer Baituola; Jie LuoORCID; Ya-Jie MengORCID; Shu-Yuan GuoORCID; Huiyong YinORCID; Shi-You JiangORCID; Yun-Feng LiORCID; Hong-Hua Miao; Yong Liu; Yan WangORCID; Bo-Liang Li; Yi-Tong MaORCID; Bao-Liang SongORCID

<jats:title>A missing link in cholesterol absorption</jats:title> <jats:p> Cholesterol is important for general health, but too much can build up in artery walls and cause cardiovascular disease. Low-density lipoprotein cholesterol (LDL-C) is often referred to as “bad cholesterol”; keeping LDL-C within stringent limits is recommended to reduce the risk of heart attack and stroke. Zhang <jats:italic>et al.</jats:italic> discovered that some individuals have an inherited frameshift mutation in the <jats:italic>LIMA1</jats:italic> gene (also known as <jats:italic>EPLIN</jats:italic> or <jats:italic>SREBP3</jats:italic> ). The gene has not been linked to lipid metabolism before, but altered <jats:italic>LIMA1</jats:italic> was found to maintain low plasma LDL-C by reducing the absorption of cholesterol through the intestine. Pharmacological targeting through the LIMA1 pathway might thus provide a strategy to improve heart health. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6393" page="1087" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aao6575">1087</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1087-1092

Background levels of methane in Mars’ atmosphere show strong seasonal variations

Christopher R. WebsterORCID; Paul R. MahaffyORCID; Sushil K. Atreya; John E. MooresORCID; Gregory J. FleschORCID; Charles MalespinORCID; Christopher P. McKayORCID; German MartinezORCID; Christina L. Smith; Javier Martin-Torres; Javier Gomez-ElviraORCID; Maria-Paz Zorzano; Michael H. WongORCID; Melissa G. TrainerORCID; Andrew SteeleORCID; Doug Archer; Brad SutterORCID; Patrice J. CollORCID; Caroline Freissinet; Pierre-Yves MeslinORCID; Raina V. GoughORCID; Christopher H. House; Alexander PavlovORCID; Jennifer L. EigenbrodeORCID; Daniel P. GlavinORCID; John C. Pearson; Didier KeymeulenORCID; Lance E. Christensen; Susanne P. SchwenzerORCID; Rafael Navarro-GonzalezORCID; Jorge Pla-García; Scot C. R. Rafkin; Álvaro Vicente-Retortillo; Henrik KahanpääORCID; Daniel Viudez-MoreirasORCID; Michael D. SmithORCID; Ari-Matti HarriORCID; Maria GenzerORCID; Donald M. HasslerORCID; Mark LemmonORCID; Joy CrispORCID; Stanley P. SanderORCID; Richard W. ZurekORCID; Ashwin R. VasavadaORCID

<jats:title>Measuring martian organics and methane</jats:title> <jats:p> The Curiosity rover has been sampling on Mars for the past 5 years (see the Perspective by ten Kate). Eigenbrode <jats:italic>et al.</jats:italic> used two instruments in the SAM (Sample Analysis at Mars) suite to catch traces of complex organics preserved in 3-billion-year-old sediments. Heating the sediments released an array of organics and volatiles reminiscent of organic-rich sedimentary rock found on Earth. Most methane on Earth is produced by biological sources, but numerous abiotic processes have been proposed to explain martian methane. Webster <jats:italic>et al.</jats:italic> report atmospheric measurements of methane covering 3 martian years and found that the background level varies with the local seasons. The seasonal variation provides an important clue for determining the origin of martian methane. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6393" page="1096" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aas9185">1096</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6393" page="1093" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aaq0131">1093</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6393" page="1068" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat2662">1068</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1093-1096

Organic matter preserved in 3-billion-year-old mudstones at Gale crater, Mars

Jennifer L. EigenbrodeORCID; Roger E. SummonsORCID; Andrew SteeleORCID; Caroline Freissinet; Maëva Millan; Rafael Navarro-GonzálezORCID; Brad SutterORCID; Amy C. McAdamORCID; Heather B. Franz; Daniel P. GlavinORCID; Paul D. Archer; Paul R. MahaffyORCID; Pamela G. ConradORCID; Joel A. HurowitzORCID; John P. GrotzingerORCID; Sanjeev GuptaORCID; Doug W. MingORCID; Dawn Y. SumnerORCID; Cyril Szopa; Charles MalespinORCID; Arnaud BuchORCID; Patrice CollORCID

<jats:title>Measuring martian organics and methane</jats:title> <jats:p> The Curiosity rover has been sampling on Mars for the past 5 years (see the Perspective by ten Kate). Eigenbrode <jats:italic>et al.</jats:italic> used two instruments in the SAM (Sample Analysis at Mars) suite to catch traces of complex organics preserved in 3-billion-year-old sediments. Heating the sediments released an array of organics and volatiles reminiscent of organic-rich sedimentary rock found on Earth. Most methane on Earth is produced by biological sources, but numerous abiotic processes have been proposed to explain martian methane. Webster <jats:italic>et al.</jats:italic> report atmospheric measurements of methane covering 3 martian years and found that the background level varies with the local seasons. The seasonal variation provides an important clue for determining the origin of martian methane. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6393" page="1096" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aas9185">1096</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6393" page="1093" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aaq0131">1093</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6393" page="1068" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat2662">1068</jats:related-article> </jats:p>

Palabras clave: Multidisciplinary.

Pp. 1096-1101