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Science
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Disponibilidad
| Institución detectada | Período | Navegá | Descargá | Solicitá |
|---|---|---|---|---|
| No detectada | desde mar. 1997 / hasta dic. 2023 | Science Journals |
Información
Tipo de recurso:
revistas
ISSN impreso
0036-8075
ISSN electrónico
1095-9203
Editor responsable
American Association for the Advancement of Science (AAAS)
País de edición
Estados Unidos
Fecha de publicación
1880-
Cobertura temática
Tabla de contenidos
Top stories: tanked alcohol trial, Aztec human sacrifice, and speedy gene construction
Katie Langin
Palabras clave: Multidisciplinary.
Pp. No disponible
Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”
Neta Shlezinger
; Henriette Irmer; Sourabh Dhingra; Sarah R. Beattie; Robert A. Cramer; Gerhard H. Braus; Amir Sharon; Tobias M. Hohl
<jats:p> Aouacheria <jats:italic>et al</jats:italic> . question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in <jats:italic>Aspergillus fumigatus</jats:italic> . Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach. </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Analysis of shared heritability in common disorders of the brain
; Verneri Anttila; Brendan Bulik-Sullivan; Hilary K. Finucane; Raymond K. Walters; Jose Bras; Laramie Duncan; Valentina Escott-Price; Guido J. Falcone; Padhraig Gormley; Rainer Malik; Nikolaos A. Patsopoulos; Stephan Ripke; Zhi Wei; Dongmei Yu; Phil H. Lee; Patrick Turley; Benjamin Grenier-Boley; Vincent Chouraki; Yoichiro Kamatani; Claudine Berr; Luc Letenneur; Didier Hannequin; Philippe Amouyel; Anne Boland; Jean-François Deleuze; Emmanuelle Duron; Badri N. Vardarajan; Christiane Reitz; Alison M. Goate; Matthew J. Huentelman; M. Ilyas Kamboh; Eric B. Larson; Ekaterina Rogaeva; Peter St George-Hyslop; Hakon Hakonarson; Walter A. Kukull; Lindsay A. Farrer; Lisa L. Barnes; Thomas G. Beach; F. Yesim Demirci; Elizabeth Head; Christine M. Hulette; Gregory A. Jicha; John S.K. Kauwe; Jeffrey A. Kaye; James B. Leverenz; Allan I. Levey; Andrew P. Lieberman; Vernon S. Pankratz; Wayne W. Poon; Joseph F. Quinn; Andrew J. Saykin; Lon S. Schneider; Amanda G. Smith; Joshua A. Sonnen; Robert A. Stern; Vivianna M. Van Deerlin; Linda J. Van Eldik; Denise Harold; Giancarlo Russo; David C. Rubinsztein; Anthony Bayer; Magda Tsolaki; Petra Proitsi; Nick C. Fox; Harald Hampel; Michael J. Owen; Simon Mead; Peter Passmore; Kevin Morgan; Markus M. Nöthen; Jonathan M. Schott; Martin Rossor; Michelle K. Lupton; Per Hoffmann; Johannes Kornhuber; Brian Lawlor; Andrew McQuillin; Ammar Al-Chalabi; Joshua C Bis; Agustin Ruiz; Mercè Boada; Sudha Seshadri; Alexa Beiser; Kenneth Rice; Sven J. van der Lee; Philip L. De Jager; Daniel H. Geschwind; Matthias Riemenschneider; Steffi Riedel-Heller; Jerome I Rotter; Gerhard Ransmayr; Bradley T. Hyman; Carlos Cruchaga; Montserrat Alegret; Bendik Winsvold; Priit Palta; Kai-How Farh; Ester Cuenca-Leon; Nicholas Furlotte; Tobias Kurth; Lannie Ligthart; Gisela M. Terwindt; Tobias Freilinger; Caroline Ran; Scott D. Gordon; Guntram Borck; Hieab H.H. Adams; Terho Lehtimäki; Juho Wedenoja; Julie E. Buring; Markus Schürks; Maria Hrafnsdottir; Jouke-Jan Hottenga; Brenda Penninx; Ville Artto; Mari Kaunisto; Salli Vepsäläinen; Nicholas G. Martin; Grant W. Montgomery; Mitja I. Kurki; Eija Hämäläinen; Hailiang Huang; Jie Huang; Cynthia Sandor; Caleb Webber; Bertram Muller-Myhsok; Stefan Schreiber; Veikko Salomaa; Elizabeth Loehrer; Hartmut Göbel; Alfons Macaya; Patricia Pozo-Rosich; Thomas Hansen; Thomas Werge; Jaakko Kaprio; Andres Metspalu; Christian Kubisch; Michel D. Ferrari; Andrea C. Belin; Arn M.J.M. van den Maagdenberg; John-Anker Zwart; Dorret Boomsma; Nicholas Eriksson; Jes Olesen; Daniel I. Chasman; Dale R. Nyholt; Richard Anney; Andreja Avbersek; Larry Baum; Samuel Berkovic; Jonathan Bradfield; Russell J. Buono; Claudia B. Catarino; Patrick Cossette; Peter De Jonghe; Chantal Depondt; Dennis Dlugos; Thomas N. Ferraro; Jacqueline French; Helle Hjalgrim; Jennifer Jamnadas-Khoda; Reetta Kälviäinen; Wolfram S. Kunz; Holger Lerche; Costin Leu; Dick Lindhout; Warren Lo; Daniel Lowenstein; Mark McCormack; Rikke S. Møller; Anne Molloy; Ping-Wing Ng; Karen Oliver; Michael Privitera; Rodney Radtke; Ann-Kathrin Ruppert; Thomas Sander; Steven Schachter; Christoph Schankin; Ingrid Scheffer; Susanne Schoch; Sanjay M. Sisodiya; Philip Smith; Michael Sperling; Pasquale Striano; Rainer Surges; G. Neil Thomas; Frank Visscher; Christopher D. Whelan; Federico Zara; Erin L. Heinzen; Anthony Marson; Felicitas Becker; Hans Stroink; Fritz Zimprich; Thomas Gasser; Raphael Gibbs; Peter Heutink; Maria Martinez; Huw R. Morris; Manu Sharma; Mina Ryten; Kin Y. Mok; Sara Pulit; Steve Bevan; Elizabeth Holliday; John Attia; Thomas Battey; Giorgio Boncoraglio; Vincent Thijs; Wei-Min Chen; Braxton Mitchell; Peter Rothwell; Pankaj Sharma; Cathie Sudlow; Astrid Vicente; Hugh Markus; Christina Kourkoulis; Joana Pera; Miriam Raffeld; Scott Silliman; Vesna Boraska Perica; Laura M. Thornton; Laura M. Huckins; N. William Rayner; Cathryn M. Lewis; Monica Gratacos; Filip Rybakowski; Anna Keski-Rahkonen; Anu Raevuori; James I. Hudson; Ted Reichborn-Kjennerud; Palmiero Monteleone; Andreas Karwautz; Katrin Mannik; Jessica H. Baker; Julie K. O’Toole; Sara E. Trace; Oliver S. P. Davis; Sietske G. Helder; Stefan Ehrlich; Beate Herpertz-Dahlmann; Unna N. Danner; Annemarie A. van Elburg; Maurizio Clementi; Monica Forzan; Elisa Docampo; Jolanta Lissowska; Joanna Hauser; Alfonso Tortorella; Mario Maj; Fragiskos Gonidakis; Konstantinos Tziouvas; Hana Papezova; Zeynep Yilmaz; Gudrun Wagner; Sarah Cohen-Woods; Stefan Herms; Antonio Julià; Raquel Rabionet; Danielle M. Dick; Samuli Ripatti; Ole A. Andreassen; Thomas Espeseth; Astri J. Lundervold; Vidar M. Steen; Dalila Pinto; Stephen W. Scherer; Harald Aschauer; Alexandra Schosser; Lars Alfredsson; Leonid Padyukov; Katherine A. Halmi; James Mitchell; Michael Strober; Andrew W. Bergen; Walter Kaye; Jin Peng Szatkiewicz; Bru Cormand; Josep Antoni Ramos-Quiroga; Cristina Sánchez-Mora; Marta Ribasés; Miguel Casas; Amaia Hervas; Maria Jesús Arranz; Jan Haavik; Tetyana Zayats; Stefan Johansson; Nigel Williams; Josephine Elia; Astrid Dempfle; Aribert Rothenberger; Jonna Kuntsi; Robert D. Oades; Tobias Banaschewski; Barbara Franke; Jan K. Buitelaar; Alejandro Arias Vasquez; Alysa E. Doyle; Andreas Reif; Klaus-Peter Lesch; Christine Freitag; Olga Rivero; Haukur Palmason; Marcel Romanos; Kate Langley; Marcella Rietschel; Stephanie H. Witt; Soeren Dalsgaard; Anders D. Børglum; Irwin Waldman; Beth Wilmot; Nikolas Molly; Claiton H.D. Bau; Jennifer Crosbie; Russell Schachar; Sandra K. Loo; James J. McGough; Eugenio H. Grevet; Sarah E. Medland; Elise Robinson; Lauren A. Weiss; Elena Bacchelli; Anthony Bailey; Vanessa Bal; Agatino Battaglia; Catalina Betancur; Patrick Bolton; Rita Cantor; Patrícia Celestino-Soper; Geraldine Dawson; Silvia De Rubeis; Frederico Duque; Andrew Green; Sabine M. Klauck; Marion Leboyer; Pat Levitt; Elena Maestrini; Shrikant Mane; Daniel Moreno- De-Luca; Jeremy Parr; Regina Regan; Abraham Reichenberg; Sven Sandin; Jacob Vorstman; Thomas Wassink; Ellen Wijsman; Edwin Cook; Susan Santangelo; Richard Delorme; Bernadette Rogé; Tiago Magalhaes; Dan Arking; Thomas G. Schulze; Robert C. Thompson; Jana Strohmaier; Keith Matthews; Ingrid Melle; Derek Morris; Douglas Blackwood; Andrew McIntosh; Sarah E Bergen; Martin Schalling; Stéphane Jamain; Anna Maaser; Sascha B. Fischer; Céline S. Reinbold; Janice M. Fullerton; Maria Grigoroiu-Serbanescu; José Guzman-Parra; Fermin Mayoral; Peter R. Schofield; Sven Cichon; Thomas W. Mühleisen; Franziska Degenhardt; Johannes Schumacher; Michael Bauer; Philip B. Mitchell; Elliot S. Gershon; John Rice; James B. Potash; Peter P. Zandi; Nick Craddock; I. Nicol Ferrier; Martin Alda; Guy A. Rouleau; Gustavo Turecki; Roel Ophoff; Carlos Pato; Adebayo Anjorin; Eli Stahl; Markus Leber; Piotr M. Czerski; Howard J. Edenberg; Cristiana Cruceanu; Ian R. Jones; Danielle Posthuma; Till F.M. Andlauer; Andreas J. Forstner; Fabian Streit; Bernhard T. Baune; Tracy Air; Grant Sinnamon; Naomi R. Wray; Donald J. MacIntyre; David Porteous; Georg Homuth; Margarita Rivera; Jakob Grove; Christel M. Middeldorp; Ian Hickie; Michele Pergadia; Divya Mehta; Johannes H. Smit; Rick Jansen; Eco de Geus; Erin Dunn; Qingqin S. Li; Matthias Nauck; Robert A. Schoevers; Aartjan TF Beekman; James A. Knowles; Alexander Viktorin; Paul Arnold; Cathy L. Barr; Gabriel Bedoya-Berrio; O. Joseph Bienvenu; Helena Brentani; Christie Burton; Beatriz Camarena; Carolina Cappi; Danielle Cath; Maria Cavallini; Daniele Cusi; Sabrina Darrow; Damiaan Denys; Eske M. Derks; Andrea Dietrich; Thomas Fernandez; Martijn Figee; Nelson Freimer; Gloria Gerber; Marco Grados; Erica Greenberg; Gregory L. Hanna; Andreas Hartmann; Matthew E. Hirschtritt; Pieter J. Hoekstra; Alden Huang; Chaim Huyser; Cornelia Illmann; Michael Jenike; Samuel Kuperman; Bennett Leventhal; Christine Lochner; Gholson J. Lyon; Fabio Macciardi; Marcos Madruga-Garrido; Irene A. Malaty; Athanasios Maras; Lauren McGrath; Eurípedes C. Miguel; Pablo Mir; Gerald Nestadt; Humberto Nicolini; Michael S. Okun; Andrew Pakstis; Peristera Paschou; John Piacentini; Christopher Pittenger; Kerstin Plessen; Vasily Ramensky; Eliana M. Ramos; Victor Reus; Margaret A. Richter; Mark A. Riddle; Mary M. Robertson; Veit Roessner; Maria Rosário; Jack F. Samuels; Paul Sandor; Dan J. Stein; Fotis Tsetsos; Filip Van Nieuwerburgh; Sarah Weatherall; Jens R. Wendland; Tomasz Wolanczyk; Yulia Worbe; Gwyneth Zai; Fernando S. Goes; Nicole McLaughlin; Paul S. Nestadt; Hans-Jorgen Grabe; Christel Depienne; Anuar Konkashbaev; Nuria Lanzagorta; Ana Valencia-Duarte; Elvira Bramon; Nancy Buccola; Wiepke Cahn; Murray Cairns; Siow A. Chong; David Cohen; Benedicto Crespo-Facorro; James Crowley; Michael Davidson; Lynn DeLisi; Timothy Dinan; Gary Donohoe; Elodie Drapeau; Jubao Duan; Lieuwe Haan; David Hougaard; Sena Karachanak-Yankova; Andrey Khrunin; Janis Klovins; Vaidutis Kučinskas; Jimmy Lee Chee Keong; Svetlana Limborska; Carmel Loughland; Jouko Lönnqvist; Brion Maher; Manuel Mattheisen; Colm McDonald; Kieran C. Murphy; Robin Murray; Igor Nenadic; Jim van Os; Christos Pantelis; Michele Pato; Tracey Petryshen; Digby Quested; Panos Roussos; Alan R. Sanders; Ulrich Schall; Sibylle G. Schwab; Kang Sim; Hon-Cheong So; Elisabeth Stögmann; Mythily Subramaniam; Draga Toncheva; John Waddington; James Walters; Mark Weiser; Wei Cheng; Robert Cloninger; David Curtis; Pablo V. Gejman; Frans Henskens; Morten Mattingsdal; Sang-Yun Oh; Rodney Scott; Bradley Webb; Gerome Breen; Claire Churchhouse; Cynthia M. Bulik; Mark Daly; Martin Dichgans; Stephen V. Faraone; Rita Guerreiro; Peter Holmans; Kenneth S. Kendler; Bobby Koeleman; Carol A. Mathews; Alkes Price; Jeremiah Scharf; Pamela Sklar; Julie Williams; Nicholas W. Wood; Chris Cotsapas; Aarno Palotie; Jordan W. Smoller; Patrick Sullivan; Jonathan Rosand; Aiden Corvin; Benjamin M. Neale
<jats:title>Brainstorming diseases</jats:title> <jats:p>Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multiple genome-wide association studies drawn from more than 200,000 patients for 25 brain-associated disorders and 17 phenotypes. Broadly, it appears that psychiatric and neurologic disorders share relatively little common genetic risk. However, different and independent pathways can result in similar clinical manifestations (e.g., psychosis, which occurs in both schizophrenia and Alzheimer's disease). Schizophrenia correlated with many psychiatric disorders, whereas the immunopathological affliction Crohn's disease did not, and posttraumatic stress syndrome was also largely independent of underlying traits. Essentially, the earlier the onset of a disorder, the more inheritable it appeared to be.</jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aap8757">eaap8757</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
In vivo brain GPCR signaling elucidated by phosphoproteomics
Jeffrey J. Liu; Kirti Sharma; Luca Zangrandi; Chongguang Chen; Sean J. Humphrey; Yi-Ting Chiu; Mariana Spetea; Lee-Yuan Liu-Chen; Christoph Schwarzer; Matthias Mann
<jats:title>Mechanisms of drug action</jats:title> <jats:p> Advanced mass spectrometry methods enable monitoring of tens of thousands of phosphorylation sites in proteins. This technology can potentially distinguish cellular signaling pathways that produce beneficial effects from those that produce unwanted side effects. Liu <jats:italic>et al.</jats:italic> treated mice with various agonists of the kappa opioid receptor (a G protein–coupled receptor) and monitored changes in phosphorylation over time in different brain regions. The phosphorylation patterns revealed distinct patterns of signaling in various brain tissues, some of which were associated with unwanted side effects. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aao4927">eaao4927</jats:related-article> </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”
Abdel Aouacheria; Kyle W. Cunningham; J. Marie Hardwick; Zdena Palková; Ted Powers; Fedor F. Severin; Libuše Váchová
<jats:p> Shlezinger <jats:italic>et al</jats:italic> . (Reports, 8 September 2017, p. 1037) report that the common fungus <jats:italic>Aspergillus fumigatus</jats:italic> , a cause of aspergillosis, undergoes caspase-dependent apoptosis-like cell death triggered by lung neutrophils. However, the technologies they used do not provide reliable evidence that fungal cells die via a protease signaling cascade thwarted by a fungal caspase inhibitor homologous to human survivin. </jats:p>
Palabras clave: Multidisciplinary.
Pp. No disponible
Emerging stem cell ethics
Douglas Sipp; Megan Munsie; Jeremy Sugarman
<jats:p>It has been 20 years since the first derivation of human embryonic stem cells. That milestone marked the start of a scientific and public fascination with stem cells, not just for their biological properties but also for their potentially transformative medical uses. The next two decades of stem cell research animated an array of bioethical debates, from the destruction of embryos to derive stem cells to the creation of human-animal hybrids. Ethical tensions related to stem cell clinical translation and regulatory policy are now center stage and a topic of global discussion this week at the International Society for Stem Cell Research (ISSCR) annual meeting in Melbourne, Australia. Care must be taken to ensure that entry of stem cell–based products into the medical marketplace does not come at too high a human or monetary price.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1275-1275
News at a glance
<jats:p>A roundup of weekly science policy and related news.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1276-1278
U.S. center will fight infections with viruses
Kelly Servick
<jats:p>Proving ground for phage therapy will organize full clinical trials of the approach.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1280-1281
Reports of inner-ear damage deepen diplomat controversy
Richard Stone
<jats:p>As mystery symptoms reported in Cuba spread to China, some blame an attack; others see "suggestion and paranoia."</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1281-1282
Rising bedrock may delay ice sheet collapse
Katie Langin
<jats:p>Its burden lightening, crust beneath West Antarctic glaciers is rebounding at a fast pace.</jats:p>
Palabras clave: Multidisciplinary.
Pp. 1283-1283