Catálogo de publicaciones - revistas

<jats:title>Neurons that regulate feeding</jats:title> <jats:p> The tuberal nucleus, an area of the hypothalamus, has not been studied in great detail. Luo <jats:italic>et al.</jats:italic> found that GABAergic somatostatin neurons in the tuberal nucleus are functionally involved in the regulation of feeding in mice (GABA, γ-aminobutyric acid) (see the Perspective by Diano). These neurons were activated by food deprivation or hunger hormone. Loss- and gain-of-function experiments indicated that these cells are necessary and sufficient to control systemic metabolic balance. This newly described regulatory center is extensively connected with other feeding control circuits via projections to other hypothalamic nuclei. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="76" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aar4983">76</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="29" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aau1419">29</jats:related-article> </jats:p>

<jats:title>Lineage losses for man's best friend</jats:title> <jats:p> Dogs have been present in North America for at least 9000 years. To better understand how present-day breeds and populations reflect their introduction to the New World, Ní Leathlobhair <jats:italic>et al.</jats:italic> sequenced the mitochondrial and nuclear genomes of ancient dogs (see the Perspective by Goodman and Karlsson). The earliest New World dogs were not domesticated from North American wolves but likely originated from a Siberian ancestor. Furthermore, these lineages date back to a common ancestor that coincides with the first human migrations across Beringia. This lineage appears to have been mostly replaced by dogs introduced by Europeans, with the primary extant lineage remaining as a canine transmissible venereal tumor. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="81" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aao4776">81</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="27" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aau1306">27</jats:related-article> </jats:p>

<jats:title>How humans got their goats</jats:title> <jats:p> Little is known regarding the location and mode of the early domestication of animals such as goats for husbandry. To investigate the history of the goat, Daly <jats:italic>et al.</jats:italic> sequenced mitochondrial and nuclear sequences from ancient specimens ranging from hundreds to thousands of years in age. Multiple wild populations contributed to the origin of modern goats during the Neolithic. Over time, one mitochondrial type spread and became dominant worldwide. However, at the whole-genome level, modern goat populations are a mix of goats from different sources and provide evidence for a multilocus process of domestication in the Near East. Furthermore, the patterns described support the idea of multiple dispersal routes out of the Fertile Crescent region by domesticated animals and their human counterparts. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="85" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aas9411">85</jats:related-article> </jats:p>

<jats:title>Ancient migrations in Southeast Asia</jats:title> <jats:p> The past movements and peopling of Southeast Asia have been poorly represented in ancient DNA studies (see the Perspective by Bellwood). Lipson <jats:italic>et al.</jats:italic> generated sequences from people inhabiting Southeast Asia from about 1700 to 4100 years ago. Screening of more than a hundred individuals from five sites yielded ancient DNA from 18 individuals. Comparisons with present-day populations suggest two waves of mixing between resident populations. The first mix was between local hunter-gatherers and incoming farmers associated with the Neolithic spreading from South China. A second event resulted in an additional pulse of genetic material from China to Southeast Asia associated with a Bronze Age migration. McColl <jats:italic>et al.</jats:italic> sequenced 26 ancient genomes from Southeast Asia and Japan spanning from the late Neolithic to the Iron Age. They found that present-day populations are the result of mixing among four ancient populations, including multiple waves of genetic material from more northern East Asian populations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="92" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat3188">92</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="88" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat3628">88</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="31" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat8662">31</jats:related-article> </jats:p>

<jats:title>Ancient migrations in Southeast Asia</jats:title> <jats:p> The past movements and peopling of Southeast Asia have been poorly represented in ancient DNA studies (see the Perspective by Bellwood). Lipson <jats:italic>et al.</jats:italic> generated sequences from people inhabiting Southeast Asia from about 1700 to 4100 years ago. Screening of more than a hundred individuals from five sites yielded ancient DNA from 18 individuals. Comparisons with present-day populations suggest two waves of mixing between resident populations. The first mix was between local hunter-gatherers and incoming farmers associated with the Neolithic spreading from South China. A second event resulted in an additional pulse of genetic material from China to Southeast Asia associated with a Bronze Age migration. McColl <jats:italic>et al.</jats:italic> sequenced 26 ancient genomes from Southeast Asia and Japan spanning from the late Neolithic to the Iron Age. They found that present-day populations are the result of mixing among four ancient populations, including multiple waves of genetic material from more northern East Asian populations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="92" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat3188">92</jats:related-article> , p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="88" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat3628">88</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6397" page="31" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat8662">31</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>