Catálogo de publicaciones - revistas

<jats:title>Sliding at the base</jats:title><jats:p>Predictions of sea level rise caused by dynamic ice sheet loss rely on a good understanding of what controls how fast the sheets slide over the ground below. The standard approach is to model motion on the basis of an assumed frictional stress between the base of the glacier and a hard underlying bed. Now, however, Stearns and van der Veen show that this method is incorrect. Instead, they suggest that net pressure at the glacier bed controls flow.</jats:p><jats:p><jats:italic>Science</jats:italic>, this issue p.<jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6399" page="273" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aat2217">273</jats:related-article></jats:p>

<jats:title>A puzzle of new particles</jats:title> <jats:p> Atmospheric particulates can be produced by emissions or form de novo. New particle formation usually occurs in relatively clean air. This is because preexisting particles in the atmosphere will scavenge the precursors of new particles and suppress their formation. However, observations in some heavily polluted megacities have revealed substantial rates of new particle formation despite the heavy loads of ambient aerosols. Yao <jats:italic>et al.</jats:italic> investigated new particle formation in Shanghai and describe the conditions that make this process possible. The findings will help inform policy decisions about how to reduce air pollution in these types of environments. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6399" page="278" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aao4839">278</jats:related-article> </jats:p>

<jats:title>Deep coral reefs are different</jats:title> <jats:p> Coral reefs are under intense pressure from anthropogenically induced climate warming and habitat destruction. It has been suggested that coral reefs in deeper waters may provide a refuge less affected by human development and climate change. Rocha <jats:italic>et al.</jats:italic> , however, show that shallow and deep reefs are biologically different. Furthermore, deep (or mesophotic) reefs are also suffering from human impacts. Thus, deep reefs do not represent a potential refuge for other reef ecosystems. Indeed, they too are threatened and need protection. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6399" page="281" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aaq1614">281</jats:related-article> </jats:p>

<jats:title>A CRISPR screen for RBC regulators</jats:title> <jats:p> Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin. Current treatments entail modulating the level of fetal hemoglobin expression. Grevet <jats:italic>et al.</jats:italic> performed a CRISPR-Cas9 screen for regulators of fetal hemoglobin in RBCs and identified heme-regulated eIF2α kinase (HRI). Depleting the kinase in RBCs led to an increase in fetal hemoglobin levels and reduced sickling of cultured human RBCs. Thus, HRI may be a therapeutic target for sickle cell disease and other hemoglobin disorders. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6399" page="285" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aao0932">285</jats:related-article> </jats:p>

<jats:title>Mechanistic insights into kidney cancer</jats:title> <jats:p> Many clear cell renal cell carcinomas (ccRCCs) have alterations to the gene encoding the von Hippel-Lindau protein (VHL). VHL is a ubiquitin ligase that degrades target proteins when they are prolyl-hydroxylated. Zhang <jats:italic>et al.</jats:italic> performed a genome-wide search for VHL target (see the Perspective by Sanchez and Simon). They identified ZHX2, a protein with structural motifs that indicate DNA binding. ZHX2 has been implicated in tumor suppression. Loss of ZHX2 inhibited signaling through the transcription factor NF-κB, and ZHX2 bound to many NF-κB target genes. Depletion of ZHX2 slowed growth of ccRCC cells in vitro and in a mouse model. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6399" page="290" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aap8411">290</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6399" page="226" related-article-type="in-this-issue" vol="361" xlink:href="10.1126/science.aau4385">226</jats:related-article> </jats:p>

<jats:p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</jats:p>