Catálogo de publicaciones - revistas

<jats:title>Making multiplexed subcellular protein maps</jats:title> <jats:p> Being able to visualize protein localizations within cells and tissues by means of immuno-fluorescence microscopy has been key to developments in cell biology and beyond. Gut <jats:italic>et al.</jats:italic> present a high-throughput method that achieves the detection of more than 40 different proteins in biological samples across multiple spatial scales. This allows the simultaneous quantification of their expression levels in thousands of single cells; captures their detailed subcellular distribution to various compartments, organelles, and cellular structures within each of these single cells; and places all this information within a multicellular context. Such a scale-crossing dataset empowers artificial intelligence–based computer vision algorithms to achieve a comprehensive profiling of intracellular protein maps to measure their responses to different multicellular, cellular, and pharmacological contexts, and to reveal new cellular states. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aar7042">eaar7042</jats:related-article> </jats:p>

<jats:title>It's all about your contacts</jats:title> <jats:p> Membrane contact sites have recently come to the fore of our understanding of interorganelle communication. Wu <jats:italic>et al.</jats:italic> review how these important structures help to promote a variety of key functions, including organelle division and lipid transfer. Focusing on contacts between the endoplasmic reticulum and a variety of organelles or the plasma membrane reveals the generality and importance of these contacts in cellular homeostasis and organismal health. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aan5835">eaan5835</jats:related-article> </jats:p>

<jats:p> For some, the world is becoming increasingly complicated in that there are ever greater responsibilities, from selecting health insurance to figuring out how much to save for retirement. Ten years ago, my friend (and Harvard law professor) Cass Sunstein and I published a book called <jats:italic>Nudge: Improving Decisions About Health, Wealth, and Happiness</jats:italic> that offered a simple idea. By improving the environment in which people choose—what we call the “choice architecture”—they can make wiser choices without restricting any options. The Global Positioning System (GPS) technology on smartphones is an example. You decide where you want to go, the app offers possible routes, and you are free to decline the advice if you decide to take a detour. Sunstein and I stressed that the goal of a conscientious choice architect is to help people make better choices “as judged by themselves.” But what about activities that are essentially nudging for evil? This “sludge” just mucks things up and makes wise decision-making and prosocial activity more difficult. </jats:p>

<jats:p>A roundup of weekly science policy and related news.</jats:p>

<jats:p>Kelvin Droegemeier is steeped in Washington science policy.</jats:p>

<jats:p>Decision to tightly regulate gene-edited plants is a blow to biotech and science, critics say.</jats:p>

<jats:p>Animal studies suggest tameness was key to language evolution.</jats:p>

<jats:p>But studies confirm treatment can slow infections in entire communities.</jats:p>

<jats:p>Evolutionary dwarfing affected living people on the island of Flores, and may explain the stature of the extinct hobbit.</jats:p>